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Leptomycin B

Leptomycin B structure

CAS No:
87081-35-4
Formula:
C33H48O6
Chemical Name:
Leptomycin B
Synonyms:
2,10,12,16,18-Nonadecapentaenoic acid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-;2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;Leptomycin B;Elactocin;PD 114720;Antibiotic CL 1957A;NSC 364372;CI 940;CL 1957A;Antibiotic CI 940;Mantuamycin;94730-69-5
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle[1].

Leptomycin B Basic Attributes

Molecular Weight：

540.736

Exact Mass：

540.73

EC Number：

617-954-4

DSSTox ID：

DTXSID9036698

HScode：

2916190090

Characteristics

PSA：

100.90000

XLogP3：

6.66

Density：

1.1±0.1 g/cm3

Melting Point：

41-44°, with prior softening (Hokanson)

Boiling Point：

725.8±60.0 °C at 760 mmHg

Flash Point：

11°(52°F)

Refractive Index：

1.542

Storage Conditions：

−20°C

Specific rotation：

D -24.5° (c = 0.70 in MeOH); D23 -157 ° (c = 0.7% in chloroform)

Safety Information

Hazard category：

Transport codes：

UN 1230 3/PG 2

wgk germany：

hazard class code：

23/25-36/38-39/23/24/25-23/24/25-11

safety instructions：

7-16-24-33-45-36/37

Marks：

F,T

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301-H311-H331-H370

GHS Classification：

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P310, P302+P352, P303+P361+P353, P304+P340, P307+P311, P311, P312, P321, P322, P330, P361, P363, P370+P378, P403+P233, P403+P235, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Leptomycin B Use and Manufacturing

Biological tool for studying nuclear localization and protein trafficking in eukaryotic cells.

Computed Properties

Molecular Weight:540.7
XLogP3:7.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:15
Exact Mass:540.34508925
Monoisotopic Mass:540.34508925
Topological Polar Surface Area:101
Heavy Atom Count:39
Complexity:1020
Undefined Atom Stereocenter Count:7
Undefined Bond Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Leptomycin B (CI 940

CAS No.: 87081-35-4

Grade: Industrial Grade

Content: 98%

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Leptomycin B

CAS No.: 87081-35-4

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