Leptomycin B
87081-35-4
98%
2026-08-15
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Leptomycin B Cat No CEI-0451 Description A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Alias LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B Appearance White to yellowish solid Product Overview An inhibitor of nuclear export CAS No 87081-35-4 Molecular Weight 472.54 Purity >98% by HPLC Storage -20 centigrade Synonyms LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B Targets XPO1 Molecular Formula C₃₃H₄₈O₆ Solubility DMSO (>15 mg/ml) or H₂O ( Shipping Conditions Gel pack category Antibiotics(c1416) cas_num 87081-35-4 Basic Info-
Product Name:
Leptomycin B
Other Name:2,10,12,16,18-Nonadecapentaenoic acid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-;2,10,12,16,18-Nonadecapentaenoic acid,19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;Leptomycin B;Elactocin;PD 114720;Antibiotic CL 1957A;NSC 364372;CI 940;CL 1957A;Antibiotic CI 940;Mantuamycin;94730-69-5
CAS No.:87081-35-4
Molecular Formula:C33H48O6
InChIKeys:InChIKey=YACHGFWEQXFSBS-XYERBDPFSA-N
Molecular Weight:540.736
Exact Mass:540.73
EC Number:617-954-4
DSSTox ID:DTXSID9036698
HScode:2916190090
Categories:
Characteristics-
PSA:
100.90000
XLogP3:6.66
Density:1.1±0.1 g/cm3
Melting Point:41-44°, with prior softening (Hokanson)
Boiling Point:725.8±60.0 °C at 760 mmHg
Flash Point:11°(52°F)
Refractive Index:1.542
Storage Conditions:−20°C
Specific rotation:D -24.5° (c = 0.70 in MeOH); D23 -157 ° (c = 0.7% in chloroform)
Hazard IdentificationClassification of the substance or mixture
Flammable liquids, Category 2
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Acute toxicity - Category 3, Inhalation
Specific target organ toxicity â single exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H225 Highly flammable liquid and vapour
H301 Toxic if swallowed
H311 Toxic in contact with skin
H331 Toxic if inhaled
H370 Causes damage to organs
Precautionary statement(s) Prevention P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.
P242 Use non-sparking tools.
P243 Take action to prevent static discharges.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].
P370+P378 In case of fire: Use ... to extinguish.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P308+P316 IF exposed or concerned: Get emergency medical help immediately.
Storage P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product