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Cefditoren pivoxil

Cefditoren pivoxil structure

CAS No:
117467-28-4
Formula:
C25H28N6O7S3
Chemical Name:
Cefditoren pivoxil
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester,(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester,[6R-[3(Z),6α,7β(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester,(6R,7R)-;ME 1207;Cefditoren pivoxil;Cefditoren pivoxyl;Meiact;Spectracef;CCRIS 7768;Cefditoren pivaloyloxymethyl ester;Cefditorin;Zostum-O;Cefditran;Ceftorin
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Off-White PowderChEBI: The pivaloyloxymethyl ester prodrug of cefditoren.Cefditoren pivoxil is an orally active third generation cephalosporin introduced in Japan as a treatment for a broad range of bacterial infections including dermatological and other community acquired infections. Cefditoren pivoxil is reported to have a broad spectrum of activity against both Gram-positive and Gramnegative bacteria, more potent than many other existing agents of its class. In particular, it shows the

Cefditoren pivoxil Basic Attributes

Molecular Weight：

620.72

Exact Mass：

620.72

EC Number：

1308068-626-2

DSSTox ID：

DTXSID2048743

HScode：

2941905990

Characteristics

PSA：

257

XLogP3：

3.20810

Appearance：

Off-White Powder

Density：

1.55±0.1 g/cm3(Predicted)

Melting Point：

127-129 °C

Refractive Index：

1.710

Storage Conditions：

-20°C Freezer

Specific rotation：

D20 -48.5° (c = 0.5 in methanol)

Safety Information

Transport codes：

NONH for all modes of transport

RTECS Number：

XI0367800

GHS Classification：

|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

(-)-(6R,7R)-2,2-dimethylpropionyloxymethyl 7-((Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido)-3-((Z)-2-(4-methylthiazol-5-yl)ethenyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate

Cefditoren pivoxil Use and Manufacturing

Uses

antidepressant

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:620.7
XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:12
Exact Mass:620.11816077
Monoisotopic Mass:620.11816077
Topological Polar Surface Area:257
Heavy Atom Count:41
Complexity:1160
Defined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

When absorbed, it is metabolized into cefditoren in the intestinal wall and exerts its antibacterial effect. It has a broad antibacterial spectrum against Gram-positive and Gram-negative bacteria, especially Gram-positive bacteria such as Staphylococcus and Streptococcus, Gram-negative bacteria such as Escherichia coli, Branhamella catarrhalis, Klebsiella, Proteus, and Haemophilus influenzae, and anaerobic bacteria such as Peptostreptococcus, Propionibacterium acnes, and Bacteroides. It is stable to β-lactamases produced by various bacteria, and also shows strong antibacterial activity against β-lactamase-producing strains.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefditoren Pivoxil Granules
Specifications	30mg(potency)/0.3g/bag

Cefditoren Pivoxil Tablets
Ingredients	The main ingredient of this product is cefditoren pivoxil, whose chemical name is: (-)-(6R, 7R)-2,2-dimethylpropionyloxymethyl 7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetylamino]-3-[(Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylate. Molecular formula: C25H28N6O7
Indication	Note on combined use: Combination use with antacids will reduce its absorption rate, and combination use with probenecid will reduce its urinary excretion rate.
Specifications	100 mg

Cefditoren Pivoxil Tablets
Specifications	100mg

See More Related Drugs

Registered Holders

ORCHID PHARMA LTD

United States
Active
Reyoung Pharmaceutical Co., Ltd.

China
Active
Zhejiang Huafang Pharmacertical Co., Ltd.

China
Active

See More Registered Holders

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