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ZENIPLATIN

ZENIPLATIN structure

CAS No:
111490-36-9
Formula:
C11H20N2O6Pt
Chemical Name:
ZENIPLATIN
Synonyms:
ZENIPLATIN;(sp-4-2)-[2，2-Bis(aminc~nethyl)-1，3-propanediol-N，N，][1，1-cyclobutanedicarboxylato(2-)-O，O’]platinum
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

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ZENIPLATIN Basic Attributes

Molecular Weight：

471.36

Exact Mass：

471.09700

Characteristics

PSA：

167

Melting Point：

210-212 °C

Boiling Point：

366.4ºC at 760 mmHg

Flash Point：

189.6ºC

Drug Information

MeSH Entry Terms：

(2,2-bis(aminomethyl)-1,3-propanediol-N,N')(1,1-cyclobutanedicarboxylato(2')-O,O')platinum(II)

ZENIPLATIN Use and Manufacturing

Methods of Manufacturing

Its preparation is completely similar to Enloplatin. 2, 2-Dibromomethyl-1-3-propanediol can be reduced by reaction with sodium azide to obtain 2, 2-diaminemethyl-1, 3-propanediol, followed by potassium chloroplatinate and Silver cyclobutane-1, 1-dicarboxylate reacts to produce the product. Similarly, potassium chloroplatinate and dimethyl sulfoxide can be reacted first and then condensed with silver cyclobutane-1, 1-dicarboxylic acid to obtain (1, 1-cyclobutanedicarboxylic acid-O, O '-) Platinum with dimethyl sulfoxide. Then, the platinum complex is reacted with 2, 2-aminomethyl propanediol to obtain a product.

Uses

Antineoplastic.

Computed Properties

Molecular Weight:473.39
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:473.112581
Monoisotopic Mass:473.112581
Topological Polar Surface Area:167
Heavy Atom Count:20
Complexity:236
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Material

2-METHYL-1,3-PROPANEDIOL

Diammonium hydrogen phosphate