Z-TRANS-4-HYDROXY-L-PROLINOL
-
Z-TRANS-4-HYDROXY-L-PROLINOL
structure -
-
CAS No:
95687-41-5
-
Formula:
C13H17NO4
-
Chemical Name:
Z-TRANS-4-HYDROXY-L-PROLINOL
-
Synonyms:
CBZ-TRANS-4-HYDROXY-L-PROLINOL;(2S,4R)4-Hydroxy-2-(hydroxymethyl)pyrrolidine, N-CBZ protected;1-CBZ-TRANS-4-HYDROXY-L-PROLINOL;N-CBZ-TRANS-4-HYDROXY-L-PROLINOL;TRANS-N-CBZ-4-HYDROXY-L-PROLINOL;Trans-N-benzyloxycarbonyl-4-hydroxy-2-hydroxymethylpyrrolidine;Z-Hyp-Ol;Benzyl (2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
- Categories:
-
CAS No:
Z-TRANS-4-HYDROXY-L-PROLINOL Use and Manufacturing
Benzyl (4R)-hydroxy-(2S)-hydroxymethylpyrrolidine-1-carboxylate (2S, 4R)-N-LBeLzyloxvcarbonvo-2-hydroxymethyl-4-hydroxvpvrrolidine (6); To a stirred, cold (0 °C) solution of intermediate (5) (58.4 g, 0.208 mol) in THF (400 mL) was added LiBH4 (3.5 g, 0.16 mol) portion-wise. The reaction mixture was stirred for 30 min at (0-5 °C) then for 4 h at room temperature. At this time, TLC (silica gel plates developed in EtOAc) showed just a trace of starting material. The thick reaction mixture was diluted in succession with H20 (250 mL) and 2 M HC1 (277 mL), and then concentrated in vacuo to remove THF. The resulting aqueous concentrate was extracted with EtOAc (4 x 175 mL). Combined EtOAc extracts were washed with brine (2 x 200 mL), dried over MgS04, and then concentrated in vacuo to give intermediate (5) as an oil (51.9 g, 99percent). Additional reactions were carried out to give a total of 227 g of product suitable for further transformation. In later preparations the more convenient commercial solution of LiBH4 in THF was usedEXAMPLE 22
Computed Properties
Molecular Weight:251.28
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:251.11575802
Monoisotopic Mass:251.11575802
Topological Polar Surface Area:70
Heavy Atom Count:18
Complexity:278
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of Z-TRANS-4-HYDROXY-L-PROLINOL
-
![China]()
CN
8 YRS
Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 95687-41-5Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
L-Cysteine
52-90-4
-
1-chloro-6-Methyl-5-nitroisoquinoline
943606-84-6
-
2-chloro-N-(2-oxothiolan-3-yl)acetamide
84611-22-3
-
N-[(Phenylmethoxy)carbonyl]-L-phenylalanylglycine Formula
13122-99-1
-
(αR)-α-[(Methoxycarbonyl)amino]benzeneacetic acid Formula
50890-96-5
-
3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-benzamide Formula
461000-66-8
-
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione Structure
2420-17-9
-
γ-Aminobenzenepropanol Structure
14593-04-5
-
What is tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
170491-63-1
-
What is (R)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
774178-39-1