TYRPHOSTIN A25
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TYRPHOSTIN A25
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CAS No:
118409-58-8
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Formula:
C10H6N2O3
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Chemical Name:
TYRPHOSTIN A25
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Synonyms:
[3,4,5-TRIHYDROXYBENZYLIDENE]MALONONITRILE;AG 82;ALPHA-CYANO-(3,4,5-TRIHYDROXY)CINNAMONITRILE;RG-50875;RARECHEM AL BX 0070;TYRPHOSTIN 25;TYRPHOSTIN RG 50875;TYRPHOSTIN AG 82
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CAS No:
Description
Yellow Green Powder
2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile is a benzenetriol.
Characteristics
108
0.55
1.569±0.06 g/cm3(Predicted)
~220°C dec.
500.8±50.0 °C(Predicted)
256.7±30.1 °C
1.743
DMSO: >50 mg/mL, clear, yellow to orange
2-8°C
Drug Information
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
(3,4,5-trihydroxybenzylidene)-malononitrile
TYRPHOSTIN A25 Use and Manufacturing
An inhibitor of epidermal growth factor receptor tyrosine kinase activity and has a reportedIC50 of 15 μM for the autophosphorylation of the EGF-receptor.
Computed Properties
Molecular Weight:202.17
XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:202.03784206
Monoisotopic Mass:202.03784206
Topological Polar Surface Area:108
Heavy Atom Count:15
Complexity:329
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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TYRPHOSTIN AG 126
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TYRPHOSTIN AG 1024 Formula
65678-07-1
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Tyrphostin AG 213 Formula
122520-86-9
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Tyrphostin B44, (+) enantiomer,(S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide Formula
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TYRPHOSTIN A51 Structure
122520-90-5
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Tyrphostin 63 Structure
5553-97-9
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