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Tyrphostin 23

Tyrphostin 23 structure

CAS No:
118409-57-7
Formula:
C10H6N2O2
Chemical Name:
Tyrphostin 23
Synonyms:
Propanedinitrile,2-[(3,4-dihydroxyphenyl)methylene]-;Propanedinitrile,[(3,4-dihydroxyphenyl)methylene]-;2-[(3,4-Dihydroxyphenyl)methylene]propanedinitrile;RG 50810;RG 50858;AG 18;AG 18 (pharmaceutical);TX 825;Tyrphostin 23;Tyrphostin AG 18;Tyrphostin A 23;2-(3,4-Dihydroxybenzylidene)malononitrile;(3,4-Dihydroxybenzylidene)malononitrile;2-[(3,4-Dihydroxyphenyl)methylidene]propanedinitrile;155070-88-5;163063-13-6
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

Yellow Powder

2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.|Tyrphostin A23 is a broad spectrum protein tyrosine kinase inhibitor that inhibits epidermal growth factor receptor, GTPase activity of transducin, aldosterone secretion in response to Angiotensin II, and suppresses the activation of MAP kinases. (NCI)

Tyrphostin 23 Basic Attributes

Molecular Weight：

186.17

Exact Mass：

186.17

UNII：

RV0GCD31OJ

DSSTox ID：

DTXSID9045215

NCI Thesaurus Code：

C1769

Characteristics

PSA：

XLogP3：

1.3

Density：

1.428±0.06 g/cm3(Predicted)

Melting Point：

225 °C

Boiling Point：

421.1±45.0 °C(Predicted)

Flash Point：

208.5±28.7 °C

Refractive Index：

1.697

Water Solubility：

Soluble in DMSO, ethanol, or DMF

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Stability/Shelf Life：

Store in refrigerator

GHS Classification：

|Warning|H371 (100%): May cause damage to organs [Warning Specific target organ toxicity, single exposure]|P260, P264, P270, P309+P311, P314, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

(3,4-dihydroxybenzylidene)malononitrile

Tyrphostin 23 Use and Manufacturing

AG 18 inhibits EGFR with IC50 of 35 μM.

Computed Properties

Molecular Weight:186.17
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:186.042927438
Monoisotopic Mass:186.042927438
Topological Polar Surface Area:88
Heavy Atom Count:14
Complexity:313
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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AG 18(Tyrphostin 23, RG-50810)

CAS No.: 118409-57-7

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Guide of Tyrphostin 23

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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Tyrphostin 23

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