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Tyrphostin 9

Tyrphostin 9 structure

CAS No:
10537-47-0
Formula:
C18H22N2O
Chemical Name:
Tyrphostin 9
Synonyms:
Propanedinitrile,2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-;Malononitrile,(3,5-di-tert-butyl-4-hydroxybenzylidene)-;Propanedinitrile,[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-;2-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;3,5-di-tert-Butyl-4-hydroxybenzylidenemalononitrile;2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol;3,5-di-tert-Butyl-4-hydroxybenzylidenemalonitrile;Malonoben;SF 6847;GCP 5126;RG 50872;AG 17;Tyrphostin AG 17;NSC 242557;Tyrphostin 9;Tyrphostin A 9;2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile;2-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-malononitrile;51601-81-1;68072-88-8;180324-80-5
Categories:
Biochemical Engineering > Amino Acids and Derivatives

Description

Tyrphostin A9(AG 17), a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. IC50 value: Target: Multi tyrosine kinaseTyrphostin A9 inhibited TNF-induced tyrosine phosphorylation of pyk2 without blocking the cells' bactericidal activity. Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor (IC50 = 500 nM). Recent findings sugg

Solid

Malonoben is an alkylbenzene. It has a role as a geroprotector.

Tyrphostin 9 Basic Attributes

Molecular Weight：

282.38

Exact Mass：

282.38

UNII：

87TE8MRS65

NSC Number：

242557

DSSTox ID：

DTXSID1042106

HScode：

2926909090

Characteristics

PSA：

67.8

XLogP3：

4.81

Appearance：

yellow solid

Density：

1.0741 (rough estimate)

Melting Point：

141-143 °C @ Solvent: Ethanol

Boiling Point：

424.99°C (rough estimate)

Flash Point：

187.7±26.5 °C

Refractive Index：

1.5700 (estimate)

Water Solubility：

ethanol: 20 mg/mL

Storage Conditions：

Store at RT

Vapor Pressure：

1.55E-06mmHg at 25°C

Safety Information

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

23/24/25

safety instructions：

36/37/39-45

RTECS Number：

OO3737000

Marks：

Precautionary statement(s)：

P261-P280-P301 + P310-P311

Hazard Statements：

H301-H311-H331

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

tyrphostin A9

Tyrphostin 9 Use and Manufacturing

SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.

Computed Properties

Molecular Weight:282.4
XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:282.173213330
Monoisotopic Mass:282.173213330
Topological Polar Surface Area:67.8
Heavy Atom Count:21
Complexity:459
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Tyrphostin 9(SF 6847, RG-50872)

CAS No.: 10537-47-0

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Guide of Tyrphostin 9

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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Tyrphostin 9

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