 Home > Encyclopedia > WYE-687

WYE-687

WYE-687 structure

CAS No:
1062161-90-3
Formula:
C28H32N8O3
Chemical Name:
WYE-687
Synonyms:
WYE-687;N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester;methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenylcarbamate;methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate
Categories:
Biochemical Engineering > Inhibitors

Description

WYE-687 is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE-687 concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively.

WYE-687 Basic Attributes

Molecular Weight：

528.60548

Exact Mass：

528.259766

DSSTox ID：

DTXSID40649396

Characteristics

PSA：

111

XLogP3：

1.36

Density：

1.4

Boiling Point：

633.2±55.0 °C at 760 mmHg

Flash Point：

336.7±31.5 °C

Refractive Index：

1.708

Drug Information

MeSH Entry Terms：

WYE-687

WYE-687 Use and Manufacturing

WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer.

Computed Properties

Molecular Weight:528.6
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:528.25973691
Monoisotopic Mass:528.25973691
Topological Polar Surface Area:111
Heavy Atom Count:39
Complexity:785
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of WYE-687

Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

WYE-687

CAS No.: 1062161-90-3

Content: 99%

Inquiry