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SB 415286

SB 415286 structure

CAS No:
264218-23-7
Formula:
C16H10ClN3O5
Chemical Name:
SB 415286
Synonyms:
1H-Pyrrole-2,5-dione,3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-;3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione;SB 415286
Categories:
Biochemical Engineering > Inhibitors

Description

SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β.

SB 415286 is a member of the class of maleimides carrying 3-chloro-4-hydroxyphenylamino and 2-nitrophenyl substituents at positions 3 and 4 respectively. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an antioxidant, a neuroprotective agent and an apoptosis inducer. It is a member of maleimides, a member of nitrobenzenes, a member of phenols, a member of monochlorobenzenes, a substituted aniline and a secondary amino compound.

SB 415286 Basic Attributes

Molecular Weight：

359.72

Exact Mass：

359.72

DSSTox ID：

DTXSID30181018

Characteristics

PSA：

124

XLogP3：

2.8

Appearance：

yellow to orange

Density：

1.6±0.1 g/cm3

Boiling Point：

595.8°C at 760 mmHg

Flash Point：

314.1±30.1 °C

Refractive Index：

1.746

Water Solubility：

DMSO: 16 mg/mL

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione

Computed Properties

Molecular Weight:359.72
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:359.0308981
Monoisotopic Mass:359.0308981
Topological Polar Surface Area:124
Heavy Atom Count:25
Complexity:617
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 264218-23-7

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