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SB 225002

SB 225002 structure

CAS No:
182498-32-4
Formula:
C13H10BrN3O4
Chemical Name:
SB 225002
Synonyms:
SB 225002;N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA;N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA
Categories:
Biochemical Engineering > Inhibitors

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Description

1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea is a nitrophenol.

SB 225002 Basic Attributes

Molecular Weight：

352.14

Exact Mass：

350.985

DSSTox ID：

DTXSID20397383

Characteristics

PSA：

107

XLogP3：

2.6

Appearance：

white to beige

Density：

1.793g/cm3

Boiling Point：

401.6°C at 760 mmHg

Flash Point：

196.7ºC

Refractive Index：

1.765

Water Solubility：

Soluble to 100mM in DMSO and to 50mM in ethanol

Storage Conditions：

-20°C

Vapor Pressure：

5.05E-07mmHg at 25°C

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Drug Information

MeSH Entry Terms：

N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea

SB 225002 Use and Manufacturing

Potent and selective CXCR2 chemokine receptor antagonist (IC 50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO α -mediated calcium mobilization in HL60 cells (IC 50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.

Computed Properties

Molecular Weight:352.14
XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:350.98547
Monoisotopic Mass:350.98547
Topological Polar Surface Area:107
Heavy Atom Count:21
Complexity:390
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 182498-32-4

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182498-32-4 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

CAS No.: 182498-32-4

Grade: Industrial Grade

Content: 95%

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