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A-674563

A-674563 structure

CAS No:
552325-73-2
Formula:
C22H22N4O
Chemical Name:
A-674563
Synonyms:
A-674563;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine;A-674563 /A674563;(2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamineA-674563;A-674563(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamineA-674563 /A674563;(S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine
Categories:
Biochemical Engineering > Inhibitors

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Description

A-674563 is a potent and selective Akt1 inhibitor with a Ki of 11 nM.

A-674563 Basic Attributes

Molecular Weight：

358.45

Exact Mass：

358.179352

UNII：

3W2X0WGW6C

DSSTox ID：

DTXSID10462115

Characteristics

PSA：

76.8

XLogP3：

3.73

Density：

1.2±0.1 g/cm3

Boiling Point：

624.4±55.0 °C at 760 mmHg

Flash Point：

331.4±31.5 °C

Refractive Index：

1.663

Drug Information

MeSH Entry Terms：

A-674563

A-674563 Use and Manufacturing

A-674563 inhibits Akt1, PKA and CDK2 with Ki of 11 nM, 16 nM and 46 nM, respectively.

Computed Properties

Molecular Weight:358.4
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:358.17936134
Monoisotopic Mass:358.17936134
Topological Polar Surface Area:76.8
Heavy Atom Count:27
Complexity:456
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of A-674563

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
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A-674563

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