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AR-42

AR-42 structure

CAS No:
935881-37-1
Formula:
C18H20N2O3
Chemical Name:
AR-42
Synonyms:
AR-42;(S)-HDAC-42,AR-42;(S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)benzamide;(S)-HDAC 42;AR-42 (HDAC-42);HDAC-42;OSU-HDAC42;AR-42 (OSU-HDAC42)
Categories:
Biochemical Engineering > Inhibitors

Description

AR-42(HDAC-42) is a HDAC inhibitor with IC50 30 nM.IC50 Value: 30 nMTarget: HDACin vivo: HDAC42 is potent in suppressing the proliferation of U87MG and PC-3 cells, in part, because of its ability to down-regulate Akt signaling. AR-42 inhibits the growth of PC-3 and LNCaP cells with IC50 of 0.48 μM and 0.3 μM, respectively. Compared to SAHA, AR-42 exhibits distinctly superior apoptogenic potency, and causes markedly greater decreases in phospho-Akt, Bcl-xL, and survivin in PC-3 cells. AR-

AR-42 has been used in trials studying the treatment of Meningioma, Acoustic Neuroma, Testicular Lymphoma, Intraocular Lymphoma, and Vestibular Schwannoma, among others.

AR-42 Basic Attributes

Molecular Weight：

312.363

Exact Mass：

312.14700

EC Number：

-0

UNII：

E0GG29V0AQ

HScode：

2924299090

Characteristics

PSA：

78.4

XLogP3：

2.8

Density：

1.223

Safety Information

Precautionary statement(s)：

P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

HDAC-42

AR-42 Use and Manufacturing

AR-42 is a broad spectrum deacetylase inhibitor of both histone and non-histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies. AR-42 is known utilized as a novel, oral cancer therapy currently in early clinical development.

Computed Properties

Molecular Weight:312.4
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:312.14739250
Monoisotopic Mass:312.14739250
Topological Polar Surface Area:78.4
Heavy Atom Count:23
Complexity:397
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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(S)-HDAC-42

CAS No.: 935881-37-1

Content: 95%

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