CYC-116
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CYC-116
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CAS No:
693228-63-6
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Formula:
C18H20N6OS
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Chemical Name:
CYC-116
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Synonyms:
CYC-116;4-(2-Amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]- 2-Pyrimidinamine;4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine;CYC-1164-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine;4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine
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CAS No:
Description
CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.
CYC-116 Use and Manufacturing
CYC116 is a potent inhibitor of Aurora A/B and VEGFR with Ki of 8.0 nM/9.2 nM and 44 nM, respectively.
Computed Properties
Molecular Weight:368.5
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:368.14193046
Monoisotopic Mass:368.14193046
Topological Polar Surface Area:117
Heavy Atom Count:26
Complexity:443
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of CYC-116
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CN
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US
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