5-Carboxy-8-hydroxyquinoline
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5-Carboxy-8-hydroxyquinoline
structure -
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CAS No:
5852-78-8
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Formula:
C10H7NO3
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Chemical Name:
5-Carboxy-8-hydroxyquinoline
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Synonyms:
5-Carboxy-8-hydroxyquinoline;8-Hydroxyquinoline-5-carboxylic Acid;IOX1;8-hydroxy-5-Quinolinecarboxylic acid;IOX 1, >=98%;JMJD2 Inhibitor, 5-carboxy-8HQ
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CAS No:
Description
IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeabi
8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines.
5-Carboxy-8-hydroxyquinoline Basic Attributes
189.16748
189.042587
JM015YQC1C
DTXSID20207236
2933499090
Characteristics
70.4
1.8
white to brown
1.5±0.1 g/cm3
301 °C (decomp)
234.7±24.6 °C
1.730
DMSO: soluble10mg/mL, clear
2-8°C
5-Carboxy-8-hydroxyquinoline Use and Manufacturing
8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.
Computed Properties
Molecular Weight:189.17
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:189.042593085
Monoisotopic Mass:189.042593085
Topological Polar Surface Area:70.4
Heavy Atom Count:14
Complexity:231
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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