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5,5′-(2,5-Furandiyl)bis[2-thiophenemethanol]

5,5′-(2,5-Furandiyl)bis[2-thiophenemethanol] structure

CAS No:
213261-59-7
Formula:
C14H12O3S2
Chemical Name:
5,5′-(2,5-Furandiyl)bis[2-thiophenemethanol]
Synonyms:
2-Thiophenemethanol,5,5′-(2,5-furandiyl)bis-;5,5′-(2,5-Furandiyl)bis[2-thiophenemethanol];NSC 652287;RITA;[Furan-2,5-diylbis(thiene-5,2-diyl)]dimethanol;[5-[5-[5-(Hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
Categories:
Biochemical Engineering > Inhibitors

Description

RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.

[5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol is a member of thiophenes.

5,5′-(2,5-Furandiyl)bis[2-thiophenemethanol] Basic Attributes

Molecular Weight：

292.37328

Exact Mass：

292.37

NSC Number：

652287

DSSTox ID：

DTXSID40327405

HScode：

29321900

Characteristics

PSA：

110

XLogP3：

Density：

1.4±0.1 g/cm3

Boiling Point：

464.9°C at 760 mmHg

Flash Point：

235.0±27.3 °C

Refractive Index：

1.661

Storage Conditions：

Store at -20°C

Drug Information

MeSH Entry Terms：

2,5-bis(5-hydroxymethyl-2-thienyl)furan

5,5′-(2,5-Furandiyl)bis[2-thiophenemethanol] Use and Manufacturing

NSC 652287, a DNA damaging agent. It induces p53 tumor suppressor protein.

Computed Properties

Molecular Weight:292.4
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:292.02278659
Monoisotopic Mass:292.02278659
Topological Polar Surface Area:110
Heavy Atom Count:19
Complexity:274
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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RITA(NSC 652287)

CAS No.: 213261-59-7

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Guide of 5,5′-(2,5-Furandiyl)bis[2-thiophenemethanol]

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
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5,5′-(2,5-Furandiyl)bis[2-thiophenemethanol]

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