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LY2109761

LY2109761 structure

CAS No:
700874-71-1
Formula:
C26H27N5O2
Chemical Name:
LY2109761
Synonyms:
LY2109761;Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-Morpholinyl)ethoxy]-;4-[5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline;LY2109761/LY-2109761;LY210976;4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]Morpholine;7-(2-morpholinoethoxy)-4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline;4-[5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinolineLY 2109761
Categories:
Biochemical Engineering > Inhibitors

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Description

LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with Kis of 38 nM and 300 nM, respectively.

LY2109761 Basic Attributes

Molecular Weight：

441.52488

Exact Mass：

441.216461

HScode：

2934999090

Characteristics

PSA：

65.3

XLogP3：

2.8

Density：

1.3±0.1 g/cm3

Boiling Point：

640.9±55.0°C at 760 mmHg

Flash Point：

341.4±31.5 °C

Refractive Index：

1.700

LY2109761 Use and Manufacturing

Heat METHANESULFONIC acid 2- [4- (2-PYRIDIN-2-YL-5, 6-dihydro-4H-pyrrolo [1, 2- B] PYRAZOL-3-YL) -QUINOLIN-7-YLOXY]-ETHYL ESTER (87 MG, 0.19 MMOL) WITH MORPHOLINE (1 mL) at 50 C for 4 hours. Remove the morpholine in vacuo and then extract the product with isopropyl alcohol : chloroform (1: 3). Wash the organic layer with sodium chloride and dry over sodium sulfate. Concentrate in vacuo to give the desired title product as a slight yellow solid (83 mg, 100percent). MS ES+m/e 442.0 (M+1).

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LY2109761

CAS No.: 700874-71-1

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