(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
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![(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/0ad6aa38a6c249bfa9600bad2416d662.png "(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile")
(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
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CAS No:
19542-67-7
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Formula:
C10H9NO2S
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Chemical Name:
(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
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Synonyms:
2-Propenenitrile,3-[(4-methylphenyl)sulfonyl]-,(2E)-;Acrylonitrile,3-(p-tolylsulfonyl)-,(E)-;2-Propenenitrile,3-[(4-methylphenyl)sulfonyl]-,(E)-;(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile;BAY 117821;BAY 11-7082;BAY 11-7821
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CAS No:
Description
ChEBI: A nitrile that is acrylonitrile in which the hydrogen located beta,trans to the cyano group is replaced by a tosyl group. It is an inhibitor of cytokine-induced IkappaB-alpha phosphorylation i cells.
Characteristics
66.3
1.4
white solid
1.237±0.06 g/cm3(Predicted)
132-133 °C
397.6±42.0 °C(Predicted)
194.3±27.9 °C
1.557
DMSO: 25 mg/mL, soluble
Store at +4°C
1.57E-06mmHg at 25°C
Safety Information
NONH for all modes of transport
3
UD1430000
P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P501
H302
(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile Use and Manufacturing
Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis.This protein kinase inhibitor (FW = 207.31 g/mol; CAS 19542-67-7; lmax = 251 nm), also named 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile, targets NF-κB activation, selectively and irreversibly blocking TNF-α- induced phosp
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(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
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