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PR-619

PR-619 structure

CAS No:
2645-32-1
Formula:
C7H5N5S2
Chemical Name:
PR-619
Synonyms:
PR-619;2,6-DiaMino-3,5-dithiocyanopyridine;3,5-dithiocyanatopyridine-2,6-diaMine;Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester;2,6-Diamino-3,5-dithiocyanopyridinePR 619;PR 619 2,6-Diamino-3,5-dithiocyanopyridine;2,6-Diaminopyridine-3,5-bis(thiocyanate);PR-619, >=98%
Categories:
Biochemical Engineering > Inhibitors

Description

PR-619 is a broad-range DUB inhibitor with EC50 of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for USP4, USP8, USP7, USP2, and USP5, respectively.

PR-619 Basic Attributes

Molecular Weight：

223.2781

Exact Mass：

222.998642

DSSTox ID：

DTXSID00384716

Characteristics

PSA：

163

XLogP3：

1.3

Appearance：

white to beige

Density：

1.6±0.1 g/cm3

Melting Point：

210℃

Flash Point：

199.3±28.7 °C

Refractive Index：

1.764

Water Solubility：

DMSO: soluble5mg/mL (clear solution)

Storage Conditions：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-37/38-41-43

safety instructions：

26-36/37/39

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H317-H318-H335

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P333+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2,6-diaminopyridine-3,5-bis(thiocyanate)

PR-619 Use and Manufacturing

PR 619 is a broad-range DUB inhibitor. A selective and general inhibitior of cellular DUB activity without direct impairment of proteasomal proteolysis. Used in the preparation of thiazolopyridines and bisthiazolopyridines.

Computed Properties

Molecular Weight:223.3
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:222.99863753
Monoisotopic Mass:222.99863753
Topological Polar Surface Area:163
Heavy Atom Count:14
Complexity:261
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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DUB Inhibitor, PR-619

CAS No.: 2645-32-1

Content: 98%

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Guide of PR-619

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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