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Timolol maleate

Timolol maleate structure

CAS No:
26921-17-5
Formula:
C13H24N4O3S.C4H4O4
Chemical Name:
Timolol maleate
Synonyms:
2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-,(2S)-,(2Z)-2-butenedioate (1:1);2-Propanol,1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-,(-)-,maleate (1:1) (salt);2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-,(S)-,(Z)-2-butenedioate (1:1) (salt);2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-,(2S)-,(2Z)-2-butenedioate (1:1) (salt);1,2,5-Thiadiazole,2-propanol deriv.;MK 950;Timolol maleate;l-Timolol maleate;Timoptol;Timacor;Timolol hydrogen maleate;Timoptic;(-)-Timolol maleate;Betime;(S)-Timolol hydrogen maleate;(S)-(-)-Timolol maleate;L-Timolol maleate;Optimol;Timorom;Rysmon TG;WP 934;Blocadren;Blocanol;Aquanil;Tenopt;Proflax;Betim;Temserin;Timacar;Timoptol XE;Istalol;Timolol LA;Timabak;Timomann;Timolet;(S)-Timolol maleate;Apimol;Ophtamolol;Timohexal;Ocumol;Timoftol;Timoptol-LA;Isralol;Timolast;116475-10-6;131628-38-1;30166-36-0
Categories:
Biochemical Engineering > Inhibitors

Description

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively). IC50 Value: 1.97 nM(Ki for β1); 2.0 nM(Ki for β2)Target: β-adrenergic receptor(S)-Timolol, 50% bioavailability following oral administration. Does not cross the blood brain barrier. Timolol maleate does appear to have some local anesthetic properties in human cornea after chronic use by susceptible individuals.

Timolol maleate Basic Attributes

Molecular Weight：

432.49

Exact Mass：

432.167877

EC Number：

248-111-5

HScode：

2934999090

Characteristics

PSA：

182.58000

XLogP3：

0.67020

Appearance：

white to off-white powder

Melting Point：

201.5-202.5 °C

Boiling Point：

704.6ºC at 760 mmHg

Flash Point：

380ºC

Water Solubility：

H2O: soluble

Storage Conditions：

Store at RT

Vapor Pressure：

7.7E-21mmHg at 25°C

Specific rotation：

24405 -12.0° (c = 5 in 1N HCl); D25 -4.2°

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-63-36/37/38

safety instructions：

36-37/39-26

RTECS Number：

UA8475000

Marks：

Xn,Xi

Precautionary statement(s)：

P280-P301 + P312 + P330

Hazard Statements：

H302-H361

Timolol maleate Use and Manufacturing

betaadrenergic blocker

Recommended Suppliers of Timolol maleate

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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(S)-Timolol maleate

CAS No.: 26921-17-5

Content: 99.00%

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

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Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

S[-]-1-[T-BUTYLAMINO]-3-(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)OXY]-2-PROPANOL MALEATE SALT

CAS No.: 26921-17-5

Grade: Pharmaceutical Grade

Content: 99%

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