2-METHOXY-6-METHYL-4(1H)-PYRIMIDINONE

The preparation method is to use O-methyl isourea salt and ethyl acetoacetate for cyclization to obtain methyl pyrimidinol. Put 200L water and 370kg isourea salt into a 1500L reactor, stir and cool to 0～5℃, slowly add about 390kg lye (30%), keep the temperature not exceeding 15℃, and then add 300kg ethyl acetoacetate dropwise. After the addition, keep at 15℃ and react for 16h. Add 30% hydrochloric acid neutralization solution dropwise to make pH=6, about 100kg hydrochloric acid is needed. Continue stirring for 2h, filter, and wash the filter cake with a small amount of water, which is the intermediate methylpyrimidinol. Methylpyrimidinol is a crystalline solid. The solubility in organic solvents is: chloroform ≥ 3.46g/100g, ethyl acetate 0.713g/100g, dichloromethane 0.681g/100g, cyclohexane 0.522g/100g, dichloroethane 0.280g/100g, Butyl acetate 0.184g/100g, benzene 0.140g/100g, chlorobenzene 0.091g/100g, toluene 0.066g/100g. The solubility in water is 1 g/100g water.

2-Methoxy-4-methyl-6-hydroxypyrimidine, also known as methylpyrimidinol, is an intermediate of the organophosphorus pesticide pyrimidinox.

Molecular Weight:140.14
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:140.058577502
Monoisotopic Mass:140.058577502
Topological Polar Surface Area:50.7
Heavy Atom Count:10
Complexity:218
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes