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Fenoprofen

Fenoprofen structure

CAS No:
31879-05-7
Formula:
C15H14O3
Chemical Name:
Fenoprofen
Synonyms:
Benzeneacetic acid,α-methyl-3-phenoxy-;Hydratropic acid,m-phenoxy-;α-Methyl-3-phenoxybenzeneacetic acid;2-(3-Phenoxyphenyl)propionic acid;3-Phenoxyhydratropic acid;2-(m-Phenoxyphenyl)propionic acid;Fenoprofen;(±)-m-Phenoxyhydratropic acid;dl-2-(3-Phenoxyphenyl)propionic acid;(±)-2-(3-Phenoxyphenyl)propionic acid;(±)-Fenoprofen;Lilly 53858;2-(3-Phenoxyphenyl)-1-propanoic acid;2-(3-Phenoxyphenyl)propanoic acid;m-Phenoxyhydratropic acid;31879-05-7
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

ChEBI: Propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of p in and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.

Fenoprofen Basic Attributes

Molecular Weight：

242.27

Exact Mass：

242.27

EC Number：

250-850-3

HScode：

2918990090

Characteristics

PSA：

46.5

XLogP3：

3.1

Density：

1.183 g/cm3

Melting Point：

168-171

Boiling Point：

168-171 °C @ Press: 0.11 Torr

Flash Point：

141.7ºC

Water Solubility：

H2O: Slight (calcium salt)

Fenoprofen Use and Manufacturing

Methods of Manufacturing

By the condensation of m-bromoacetophenone with sodium phenoxide, m-phenoxyacetophenone is obtained, which is then prepared through the steps of hydrogenation, bromination, cyano, and hydrolysis.

Uses

antiinflammatory