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Nefopam

Nefopam structure

CAS No:
13669-70-0
Formula:
C17H19NO
Chemical Name:
Nefopam
Synonyms:
1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-5-methyl-1-phenyl-;3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine;Nefopam;Fenazoxine;(±)-Nefopam;24358-93-8;69319-32-0
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine is a member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively. It is a benzoxazocine and a tertiary amino compound.|Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.|Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)

Nefopam Basic Attributes

Molecular Weight：

253.34

Exact Mass：

253.34

EC Number：

237-148-2

NSC Number：

757856

DSSTox ID：

DTXSID2048535

ATC Code：

N02BG06|N - Nervous system

HScode：

2933990090

Characteristics

PSA：

12.5

XLogP3：

3.44

Density：

1.0078 (rough estimate)

Boiling Point：

396.54°C (rough estimate)

Flash Point：

109.0±28.8 °C

Refractive Index：

1.5400 (estimate)

Vapor Pressure：

1.18E-05mmHg at 25°C

Collision Cross Section：

157.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|157.6 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated]

Drug Information

MeSH：

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

MeSH Entry Terms：

Acupan

Nefopam Use and Manufacturing

Methods of Manufacturing

2-[[N-(2-hydroxyethyl)-N-methyl]amine]methyldiphenyl is prepared by reacting 2-benzoylbenzoic acid with thionyl chloride and then reacting with 2-methylaminoethanol Methanol is heated together with p-toluenesulfonic acid and benzene to steam benzene, and the resulting oily substance is alkalized to obtain the nefopam base.

Uses

Analgesic.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:253.34
XLogP3:2.9
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:253.146664230
Monoisotopic Mass:253.146664230
Topological Polar Surface Area:12.5
Heavy Atom Count:19
Complexity:274
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Activated charcoal

Benzoic acid

Thionyl chloride

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3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

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CAS No.: 13669-70-0

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