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Vindesine sulfate

Vindesine sulfate structure

CAS No:
59917-39-4
Formula:
C43H55N5O7.H2O4S
Chemical Name:
Vindesine sulfate
Synonyms:
Vincaleukoblastine,3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-,sulfate (1:1);Vincaleukoblastine,3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-,sulfate (1:1) (salt);1H-Indolizino[8,1-cd]carbazole,vincaleukoblastine deriv.;2H-3,7-Methanoazacycloundecino[5,4-b]indole,vincaleukoblastine deriv.;Vindesine sulfate;Desacetylvinblastine amide sulfate;DAVA;Lilly 99094;NSC 245467;Eldesine;Eldisine;LY 099094;Fildesin;Xi Ai Ke Vial
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Amorphous Solid

Vindesine sulfate is an alkaloid sulfate salt. It has a role as an antineoplastic agent. It derives from a vindesine.|Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).

Vindesine sulfate Basic Attributes

Molecular Weight：

852

Exact Mass：

851.377502

EC Number：

261-984-7

DSSTox ID：

DTXSID0049074

HScode：

2942000000

Characteristics

PSA：

247.80000

XLogP3：

3.80150

Appearance：

off-white to light yellow

Density：

1.41 g/cm3

Melting Point：

>250 °C

Water Solubility：

deionized water: ≥50mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice, rats (mg/kg): 6.3 ± 0.6, 2.0 ± 0.2 i.v. (Todd); in mice: 8.8 ± 2.5 i.p. (Owellen, Biochem. Pharmacol.)

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

1544

wgk germany：

hazard class code：

safety instructions：

26-36

RTECS Number：

YY8090000

Marks：

GHS Classification：

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P310, P305+P351+P338, P308+P313, P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)|Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)

MeSH Entry Terms：

Compound 112531

Vindesine sulfate Use and Manufacturing

Synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. Antineoplastic

Computed Properties

Molecular Weight:852.0
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:7
Exact Mass:851.37752882
Monoisotopic Mass:851.37752882
Topological Polar Surface Area:248
Heavy Atom Count:60
Complexity:1650
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It is a cell cycle-specific antitumor drug that inhibits the polymerization of intracellular tubulin, prevents the formation of spindles in the mitosis of proliferating cells, and stops cell division at the metaphase of mitosis. This product has a broad antitumor spectrum for transplanted animal tumors and has no complete cross-resistance with vinblastine and vincristine.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Vindesine Sulfate for Injection
Ingredients	『Ingredients』Vindesinesulfate
Indication	Not yet clear.
Specifications	4mg
Manufacturer	Cisen Pharmaceutical Co., Ltd.

Vindesine Sulfate for Injection
Ingredients	『Ingredients』Vindesinesulfate
Indication	1. Bone marrow suppression: the most common is a decrease in white blood cells, followed by a decrease in platelets, which has a certain effect on hemoglobin. 2. Gastrointestinal reactions: mild loss of appetite, nausea and vomiting. 3. Neurotoxicity: reversible peripheral neuritis is milder than that of vincristine, and may cause abdominal distension and constipation. 4. Reproductive toxicity and teratogenicity: pregnant women should not use it. 5. Local tissue irritation reaction: it can cause phlebitis, and it should be avoided from leaking out of the blood vessels and splashing into the eyes.
Specifications	4mg

Vindesine Sulfate for Injection
Ingredients	『Ingredients』Vindesinesulfate
Indication	Not yet clear.
Specifications	1mg
Manufacturer	Cisen Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Guangzhou Baiyunshan Hanfang Modern Pharmaceutical Co., Ltd.

China
Active
Minsheng Group Shaoxing Pharmaceutical Co., Ltd.

China
Active
Yangtze River Pharmaceutical Group Jiangsu HaiCi Biological Pharmaceutical Co., Ltd.

China
Active

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