 Home > Encyclopedia > Lobenzarit

Lobenzarit

Lobenzarit structure

CAS No:
63329-53-3
Formula:
C14H10ClNO4
Chemical Name:
Lobenzarit
Synonyms:
Benzoic acid,2-[(2-carboxyphenyl)amino]-4-chloro-;2-[(2-Carboxyphenyl)amino]-4-chlorobenzoic acid;Lobenzarit;N-(2-Carboxyphenyl)-4-chloroanthranilic acid;CCA;2-(2-Carboxyanilino)-4-chlorobenzoic acid
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Request for Quotation

Description

Lobenzarit is an aminobenzoic acid.

Lobenzarit Basic Attributes

Molecular Weight：

291.69

Exact Mass：

291.69

UNII：

915EE91P39

DSSTox ID：

DTXSID20212709

Characteristics

PSA：

86.6

XLogP3：

6.91

Density：

1.5±0.1 g/cm3

Melting Point：

>306 °C

Boiling Point：

481.0±45.0 °C at 760 mmHg

Flash Point：

244.7±28.7 °C

Refractive Index：

1.700

Toxicity：

LD50 in male, female rats (mg/kg): 2100, 2600 orally (Tanemura)

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 3261 8/PG 2

wgk germany：

hazard class code：

R34:Causes burns.

safety instructions：

S26-S27-S28-S36/37/39-S45

Marks：

Drug Information

MeSH：

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)

MeSH Entry Terms：

2-((2-carboxyphenyl)amino)-4-chlorobenzoic acid

Lobenzarit Use and Manufacturing

Methods of Manufacturing

2, 4-Dichlorobenzoic acid and 2-aminobenzoic acid in isoamyl alcohol, potassium carbonate and copper powder, reflux to obtain chlorbenzaride.

Uses

Non-steroidal anti-inflammatory drug, and it can regulate abnormal body immune function. Used for chronic rheumatoid arthritis.

Computed Properties

Molecular Weight:291.68
XLogP3:5.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:291.0298355
Monoisotopic Mass:291.0298355
Topological Polar Surface Area:86.6
Heavy Atom Count:20
Complexity:376
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Isoamyl alcohol