Seratrodast
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Seratrodast
structure -
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CAS No:
112665-43-7
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Formula:
C22H26O4
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Chemical Name:
Seratrodast
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Synonyms:
Benzeneheptanoic acid,ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-;Benzeneheptanoic acid,ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-,(±)-;ζ-(2,4,5-Trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)benzeneheptanoic acid;AA 2414;(±)-2,4,5-Trimethyl-3,6-dioxo-ζ-phenyl-1,4-cyclohexadiene-1-heptanoic acid;Seratrodast;ABT 001;A 73001;Abbott 73001;7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid;Seratodrast;Bronica;7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid;103186-19-2
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CAS No:
Description
Pale Orange SolidSeratrodast, a novel benzoquinone derivative, is the first thromboxane A2(TxA2) receptor antagonist to reach the market. It is orally active for the treatment of bronchospastic disorders such as asthma. TxA2, a metabolite of the arachidonate cascade, is involved in several cardiovascular and respiratory diseases through its potent biological effects on platelet aggregation and constriction of vascular and respiratory smooth muscles.
Seratrodast is an organic molecular entity.|Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma.
Seratrodast Basic Attributes
354.44
354.44
1312995-182-4
759640
DTXSID4021397
R - Respiratory system
29309070
Characteristics
71.4
4.4
1.140±0.06 g/cm3(Predicted)
128-129 °C
522.3±49.0 °C(Predicted)
283.8±26.3 °C
1.555
Store at +4°C
Safety Information
Ⅲ
6.1
2811
3
6.1
S26-S24/25
DA1600050
Xi
P201-P308 + P313
H361d
|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds that inhibit the action of prostaglandins. (See all compounds classified as Prostaglandin Antagonists.)
Seratrodast has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-[7-phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoyl]oxyoxane-2-carboxylic acid.
7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
Seratrodast Use and Manufacturing
antibacterial.Prothrombin A2 antagonist. Used to treat asthma. Used as an antiasthmatic
Computed Properties
Molecular Weight:354.4
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:354.18310931
Monoisotopic Mass:354.18310931
Topological Polar Surface Area:71.4
Heavy Atom Count:26
Complexity:633
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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