 Home > Encyclopedia > Pranlukast

Pranlukast

Pranlukast structure

CAS No:
103177-37-3
Formula:
C27H23N5O4
Chemical Name:
Pranlukast
Synonyms:
Benzamide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-;Benzamide,N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-;N-[4-Oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide;RS 411;ONO 1078;Pranlukast;ONO-RS 411;SB 205312;8-[4-(4-Phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran;Onon;CCN 00401;Azlaire;4-Oxo-8-[4-(4-phenylbutoxy)benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzopyran
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

Off-white solidPranlukast, a novel chromone derivative, was introduced in Japan for the treatment of bronchial asthma and allergic diseases. Pranlukast is a highly potent, selective and competitive antagonist of peptidoleukotrienes with high affinity for the LTD4 receptor. The therapeutic potential of pranlukast in managing irritable bowel syndrome has been suggested. Pranlukast is a common respiratory drug, it belongs to asthma drugs.

N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide is a member of chromones.|Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

Pranlukast Basic Attributes

Molecular Weight：

481.5

Exact Mass：

481.50

EC Number：

201-616-4

UNII：

TB8Z891092

DSSTox ID：

DTXSID9021180|DTXSID3043782

ATC Code：

R - Respiratory system

Characteristics

PSA：

119

XLogP3：

4.2

Appearance：

off-white solid

Density：

1.374±0.06 g/cm3(Predicted)

Melting Point：

236-238°C

Refractive Index：

1.681

Storage Conditions：

Store at +4°C

Toxicity：

LD50 in male mice (mg/kg): >1000 i.v. (Toda)

Safety Information

hazard class code：

11-34

safety instructions：

16-26-36/37/39-45

RTECS Number：

CV5647500

Marks：

F,C

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Toxicity

Toxicity Summary：

Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.

Drug Information

Drug Indication：

Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists.

Pharmacology：

Pranlukast is a cysteinyl leukotriene receptor-1 antagonist.

MeSH：

A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level. (See all compounds classified as Leukotriene Antagonists.)|Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)

Metabolism/Metabolites：

Hepatic

Mechanism of Action：

Pranlukast selectively antagonizes leukotriene D₄ (LTD₄) at the cysteinyl leukotriene receptor, CysLT₁, in the human airway. Pranlukast inhibits the actions of LTD₄ at the CysLT₁ receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

MeSH Entry Terms：

8-(4 (4-phenylbutoxy)benzoyl)amino-2-(tetrazol-5'-yl)-4-oxo-4H-1-benzopyran

Pranlukast Use and Manufacturing

Labeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry.Premastast is a commonly used respiratory medicine, belongs to antiasthmatic drugs, is a cysteine leukotriene (LTs) receptor antagonist, and selectively binds with LTC4, LTD4, LTE4 receptors to antagonize its effect .

Computed Properties

Molecular Weight:481.5
XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:481.17500423
Monoisotopic Mass:481.17500423
Topological Polar Surface Area:119
Heavy Atom Count:36
Complexity:778
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pranlukast
Manufacturer	Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Pranlukast

Registered Holders

Cheer Fine Pharmaceutical Co., Ltd.

Japan
Active
Beijing Fuweisi Biotechnology Co., Ltd.

China
Active
Jiangsu Hengrui Pharmaceuticals Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Pranlukast

Dayang Chem (Hangzhou) Co.,Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of N-Diethyl-m-toluamide,6-Methyluracil,Anisole,4-Dimethoxybenzoic acid,CS (lacrimator),Daucosterol,N,N-Formylmorpholine,Epichlorohydrin,Tetramethylguanidine,Dimethicone,3

Pranlukast Manufacturer/High quality/Best price/In stock

CAS No.: 103177-37-3

Grade: Industrial Grade

Inquiry
Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Pranlukast >=98.0% API Pharmaceutical made in china

CAS No.: 103177-37-3

Inquiry
Xian ZB Biotech Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Herb Extracts,Cosmetic raw materails,API

Antiasthmatic Drugs Pranlukast Powder CAS 103177-37-3 Pranlukast

CAS No.: 103177-37-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Pranlukast103177-37-3

CAS No.: 103177-37-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Shandong Ailike New Material Technology Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of API,Antibiotics,Anti cancer category

Pranlukast

CAS No.: 103177-37-3

Grade: Industrial Grade

Content: 98%

Inquiry