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Suplatast tosilate

Suplatast tosilate structure

CAS No:
94055-76-2
Formula:
C16H26NO4S.C7H7O3S
Chemical Name:
Suplatast tosilate
Synonyms:
Sulfonium,[3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl-,4-methylbenzenesulfonate (1:1);Sulfonium,[3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl-,salt with 4-methylbenzenesulfonic acid (1:1);Suplatast tosilate;Suplatast tosylate;IPD 1151T;[2-[4-(3-Ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium p-toluenesulfonate;(±)-[2-[4-(3-Ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylsulfonium p-toluenesulfonate;160114-29-4;1776086-79-3
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

Suplatast tosilate(IPD 1151T) is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. IC50 value:Target: Th2 cytokine inhibitorSuplatast Tosilate acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Suplatast Tosilate(IPD 1151T) exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.

Suplatast tosilate Basic Attributes

Molecular Weight：

499.64062

Exact Mass：

499.169830

DSSTox ID：

DTXSID9045003

Characteristics

PSA：

134

Appearance：

white to off-white

Melting Point：

70-73 °C

Water Solubility：

DMSO: >20mg/mL

Storage Conditions：

Store at RT

Toxicity：

LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

WR7906000

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

GHS Classification：

|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)

MeSH Entry Terms：

(2-(4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate

Suplatast tosilate Use and Manufacturing

Methods of Manufacturing

Add 5.0 g (15.95 mmol) of intermediate 3 to the reaction flask at 20~30 °C.5.94 g of p-toluenesulfonic acid methyl ester (31.91 mmol), stir to 50-60 ° C, react for 20-24 h, add 10 mL of acetone for 30 minutes, filter, filter cake and add 20 mL of acetone to recrystallize to obtain metformin. 6.8 g, yield 85.0

Uses

Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.

Computed Properties

Molecular Weight:499.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:499.16984474
Monoisotopic Mass:499.16984474
Topological Polar Surface Area:134
Heavy Atom Count:33
Complexity:500
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Sulfalast Tosylate Granules
Ingredients	(2-(4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate. Molecular weight: C16H26NO4SC7H7O3S; C23H
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	1g:50mg (1g of this product contains 50mg of Sulfalastat Tosylate)
Manufacturer	Zein BIOTECHNOLOGY Co., Ltd.

Sulfalastat Tosilate

Registered Holders

Zein BIOTECHNOLOGY Co., Ltd.

China
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Suplatast Tosylate

CAS No.: 94055-76-2

Content: 0.98%

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