 Home > Encyclopedia > 3-AMINO-5-FLUOROPYRIDINE

3-AMINO-5-FLUOROPYRIDINE

3-AMINO-5-FLUOROPYRIDINE structure

CAS No:
210169-05-4
Formula:
C5H5FN2
Chemical Name:
3-AMINO-5-FLUOROPYRIDINE
Synonyms:
3-AMINO-5-FLUOROPYRIDINE;3-Pyridinamine,5-fluoro-(9CI);3-AMINO-5-FLUOROPYRIDINE 97%;5-Fluoropyridin-3-amine;5-Fluoropyridin-3-ylamine;3-Amine-5-fluoro-pyridin;3-AMine-5-fluoro-pyridine;3-PyridinaMine,5-fluoro-
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

Description

Light yellow Cryst

3-AMINO-5-FLUOROPYRIDINE Basic Attributes

Molecular Weight：

112.11

Exact Mass：

112.043678

EC Number：

-0

HScode：

2933399090

Characteristics

PSA：

38.9

XLogP3：

0.3

Appearance：

light yellow cryst

Density：

1.3±0.1 g/cm3

Melting Point：

86°C

Boiling Point：

232.7°C at 760 mmHg

Flash Point：

85.1±21.8 °C

Refractive Index：

1.554

Vapor Pressure：

3.29mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38-22

safety instructions：

26-36-36/37

Marks：

Xi,Xn

Hazard note：

Irritant

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (93.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

3-AMINO-5-FLUOROPYRIDINE Use and Manufacturing

Methods of Manufacturing

To a solution of General procedure: A microwave tube was charged with 6'-bromo-8'-chloro-2'H-spiro[cyclohexane-1, 3'-imidazo[1, 5-a]pyridine]-1', 5'-dione 3 (1.00 eq.), amine (1.00 eq.), Cs2CO3 (2.00 eq.), Pd2(dba)3 (0.10 eq.), xantphos (0.10 eq.) and 1, 4-dioxane (4 mL). The reaction mixture was heated under microwave irradiation at 130 C for 30 min, concentrated under reduced pressure, and purified by flash column chromatography (silica gel, DCM ramping to DCM/CH3OH = 9:1) to yield the desired product.

Uses

Reactant for:• ;Preparation of nonpeptide inhibitors of measles virus entry1

Computed Properties

Molecular Weight:112.10
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:112.04367633
Monoisotopic Mass:112.04367633
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:76.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzyl alcohol

1,2-Dichloroethane

Hexane

Tetrafluoroboric acid

Ethanol

Hydrochloric acid

Recommended Suppliers of 3-AMINO-5-FLUOROPYRIDINE

Wuhan Oner Biotech Co.,Ltd. Contact Supplier

CN
6 YRS

Business licensed

Distributor Supplier of Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Pharmaceutical intermediate 3-Amino-5-fluoropyridine

Unit Price: $7.07-8.08 /KG FOB

CAS No.: 210169-05-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

3-Amino-5-fluoropyridine

CAS No.: 210169-05-4

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high quality 3-AMINO-5-FLUOROPYRIDINE 99% transparent liquid KANBEI

CAS No.: 210169-05-4

Grade: Industrial Grade

Content: 99%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

3-AMINO-5-FLUOROPYRIDINE

CAS No.: 210169-05-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry