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3-AMINO-5-HYDROXYMETHYLPYRIDINE

3-AMINO-5-HYDROXYMETHYLPYRIDINE structure

CAS No:
443649-18-1
Formula:
C6H8N2O
Chemical Name:
3-AMINO-5-HYDROXYMETHYLPYRIDINE
Synonyms:
3-AMINO-5-HYDROXYMETHYLPYRIDINE;3-Pyridinemethanol,5-amino-(9CI);3-Amino-5-hydroxymethylpyridine ,97%;(5-Aminopyridin-3-yl)methanol;3-PyridineMethanol,5-aMino-
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

White to light yellow solid

3-AMINO-5-HYDROXYMETHYLPYRIDINE Basic Attributes

Molecular Weight：

124.14

Exact Mass：

124.063660

DSSTox ID：

DTXSID00652164

HScode：

2933399090

Characteristics

PSA：

59.1

XLogP3：

-0.7

Density：

1.3±0.1 g/cm3

Boiling Point：

367.2°C at 760 mmHg

Flash Point：

175.9±23.7 °C

Refractive Index：

1.628

Safety Information

hazard class code：

22-36/37/38

safety instructions：

Marks：

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

3-AMINO-5-HYDROXYMETHYLPYRIDINE Use and Manufacturing

5-Amino-nicotinic acid methyl ester (5.7g, 30.2mmol) was dissolved in THF (150ml) and LiAIH5-Amino-nicotinic acid methyl ester (5.7g, 30.2mmol) was dissolved in THF (150ml) and LiAIH4 (1 M in THF solution 133ml, 133mmol) added slowly at O0C. The reaction mixture was stirred at room temperature for 21 h. The reaction mixture was quenched and acidified to pH 3 using dilute HCI, and basified (pH 8) using solid Na2CO3. Solvents were removed under reduced pressure. The residue was filtered through silica gel using 20percent MeOH/DCM yielding the product 3.8g, (100percent) with LCMS purity 97percent, m/z 125 [M++H]+, by ELSMethyl 5-aminonicotinate (250 mg, 1.643 mmol) was dissolved in THF (20 mL) at 0 °C. LAH (6.57 mL, 6.57 mmol, 1 M in THF) was added dropwise to the solution over 2 minutes. The reaction mixture was then allowed to warm to room temperature and stirred at room temperature for 1.5 hours. The reaction mixture was then quenched water256 at 0 °C (lmL), followed by addition of 1M NaOH (2mL) and an additional 4 mL of water. The quenched reaction mixture was stirred for 10 minutes at room temperature then magnesium sulfate was added. The mixture was filtered through celite and the filtrate was concentrated to yield the intermediate alcohol. This cmde alcoholintermediate was reacted according to Procedure Ito yield Intermediate 1-119 (251 mg, 1.05 mmol, 65percent yield) after silica chromatography. LC-MS: Method H, MS (ESI) m/z:239.2 (M+H)tA E2 (55 rng, 0.1 rnrnoi). 247 (22 mg, 0.1 rnrnoi), and triphenyiphosphine (58 mg, 0.2 mrnol) in TI-IF (3 mL) is stirred at room temperature for 10 minutes. DIAD (44 Ing, 0, 2 mmoi) is then added at '5 0 After stirring at room temperature for 16 hours, the mixture is concentrated and purified by silica gel column chromatography (MeOH:DCM 1:100) to give E20 as avellow solid (35 111g. 45percent yield), (MS: [M-4-F1] 480.0)

Computed Properties

Molecular Weight:124.14
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:124.063662883
Monoisotopic Mass:124.063662883
Topological Polar Surface Area:59.1
Heavy Atom Count:9
Complexity:87.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Tetrahydrofuran

Thionyl chloride

Recommended Suppliers of 3-AMINO-5-HYDROXYMETHYLPYRIDINE

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

3-AMINO-5-HYDROXYMETHYLPYRIDINE

CAS No.: 443649-18-1

Grade: Industrial Grade

Content: 99.0%

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Compound Net Biotechnology Inc. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

443649-18-1 (5-aminopyridin-3-yl)methanol

CAS No.: 443649-18-1

Grade: Industrial Grade

Content: 95%

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Guide of 3-AMINO-5-HYDROXYMETHYLPYRIDINE

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
Latest News
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3-AMINO-5-HYDROXYMETHYLPYRIDINE

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