1-Acetyl-4-(4-hydroxyphenyl)piperazine
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1-Acetyl-4-(4-hydroxyphenyl)piperazine
structure -
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CAS No:
67914-60-7
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Formula:
C12H16N2O2
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Chemical Name:
1-Acetyl-4-(4-hydroxyphenyl)piperazine
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Synonyms:
Ethanone,1-[4-(4-hydroxyphenyl)-1-piperazinyl]-;Piperazine,1-acetyl-4-(4-hydroxyphenyl)-;1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone;T 1141;1-Acetyl-4-(p-hydroxyphenyl)piperazine;1-Acetyl-4-(4-hydroxyphenyl)piperazine;4-(4-Acetylpiperazino)phenol;1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanone;4-(4-Acetylpiperazin-1-yl)phenol;1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethan-1-one;1229612-23-0
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CAS No:
1-Acetyl-4-(4-hydroxyphenyl)piperazine Basic Attributes
220.27
220.27
795777
267-744-8
DTXSID3057804
29214910
Characteristics
43.8
0.19
White to slightly pink or beige Powder
1.2±0.1 g/cm3
180 °C @ Solvent: Ethanol
456.5±40.0 °C at 760 mmHg
229.9±27.3 °C
1.585
H2O: 4.3 g/L (20 ºC)
-20°C Freezer
Safety Information
NONH for all modes of transport
3
36/37/38-22
26-36-36/37/39-22
Xi,Xn
Stable under normal temperatures and pressures.
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (96%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 50 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-Acetyl-4-(4-hydroxyphenyl)piperazine Use and Manufacturing
Piperazine hexahydrate can be first condensed with p-nitrochlorobenzene to generate 1-(4-nitrophenyl)piperazine, and then react with acetic anhydride to obtain 1-acetyl-4-(4-nitrophenyl)piper Oxazine, the latter is obtained after nitro reduction, diazotization, and hydrolysis.
Used in the synthesis of ketoconazole and itraconazole
Computed Properties
Molecular Weight:220.27
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:220.121177757
Monoisotopic Mass:220.121177757
Topological Polar Surface Area:43.8
Heavy Atom Count:16
Complexity:241
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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1-Acetyl-4-(4-hydroxyphenyl)piperazine
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