Levalbuterol hydrochloride
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Levalbuterol hydrochloride
structure -
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CAS No:
50293-90-8
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Formula:
C13H21NO3.ClH
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Chemical Name:
Levalbuterol hydrochloride
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Synonyms:
1,3-Benzenedimethanol,α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-,hydrochloride (1:1),(α1R)-;1,3-Benzenedimethanol,α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-,hydrochloride,(R)-;1,3-Benzenedimethanol,α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-,hydrochloride,(α1R)-;(-)-Salbutamol hydrochloride;(R)-Salbutamol hydrochloride;Levalbuterol hydrochloride;Xopenex;Levosalbutamol hydrochloride;(R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol hydrochloride
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CAS No:
Description
Off-White Solid
Levalbuterol Hydrochloride is the hydrochloride salt form of levalbuterol, a relatively selective sympathomimetic beta-2 adrenergic receptor agonist with bronchodilator activity. Levalbuterol hydrochloride binds to beta-2 adrenergic receptors in bronchial smooth muscle and activates intracellular adenyl cyclase, thereby increasing the production of cyclic-3', 5'-adenosine monophosphate (cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation of bronchial smooth muscles. The increased cyclic AMP concentrations also inhibit the release of inflammatory mediators from mast cells.|The R-isomer of albuterol.
Levalbuterol hydrochloride Basic Attributes
275.77168
275.128815
WDQ1526QJM
759255
DTXSID20198296
C47580
2922504500
Characteristics
72.7
2.49890
white to tan
169-171°C
433.5ºC at 760 mmHg
H2O: ≥15mg/mL
-20°C Freezer
D20 -32.2° (c = 0.1 in water)
158.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
22-37/38-41
26-39
Xn
P280-P301 + P312 + P330-P305 + P351 + P338 + P310
H302-H315-H318-H335
|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Levalbuterol hydrochloride Use and Manufacturing
Antiasthmatic
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:275.77
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:275.1288213
Monoisotopic Mass:275.1288213
Topological Polar Surface Area:72.7
Heavy Atom Count:18
Complexity:227
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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