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2-Amino-3-bromo-6-methylpyridine

2-Amino-3-bromo-6-methylpyridine structure

CAS No:
126325-46-0
Formula:
C6H7BrN2
Chemical Name:
2-Amino-3-bromo-6-methylpyridine
Synonyms:
TIMTEC-BB SBB005516;2-AMINO-3-BROMO-6-METHYLPYRIDINE;2-AMINO-3-BROMO-6-PICOLINE;3-BROMO-6-METHYLPYRIDIN-2-AMINE;3-BROMO-6-METHYL-PYRIDIN-2-YLAMINE;6-AMINO-5-BROMO-2-PICOLINE;BUTTPARK 43\57-93;2-AMINO-3-BROMO-6-PICOLINE (2-AMINO-3-BROMO-6-METHYLPYRIDINE)
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Light yellow Cryst

2-Amino-3-bromo-6-methylpyridine Basic Attributes

Molecular Weight：

187.04

Exact Mass：

185.979248

DSSTox ID：

DTXSID00370295

HScode：

29333999

Characteristics

PSA：

38.9

XLogP3：

1.6

Appearance：

Off-white Solid

Density：

1.5672 (rough estimate)

Melting Point：

77-79°C

Boiling Point：

238.5±35.0 °C(Predicted)

Flash Point：

98.1±25.9 °C

Refractive Index：

1.5500 (estimate)

Storage Conditions：

Keep Cold

Vapor Pressure：

0.0422mmHg at 25°C

Safety Information

Hazard category：

6.1

hazard class code：

36/37/38-22

safety instructions：

26-36

Marks：

Xi,Xn

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

2-Amino-3-bromo-6-methylpyridine Use and Manufacturing

Step 1 [0662] Step 1: 6-Methyl-3-(prop-1-en-2-yl)pyridin-2-amine. A mixture of 2-amino-3- bromo-6-methylpyridine (5 g, 26.7 mmol, Waterstone Technology, LLC, Carmel, IN), dichloro[1, 1'-bis(diphenylphosphino)ferrocene]dichloride palladium(II) DCM adduct (0.218 g, 0.267 mmol), 2-isopropenylboronic acid, pincol ester (8.09 g, 48.1 mmol, Combi-Blocks, San Diego, CA), and aqueous sodium carbonate (10% solution in 51 mL of water; 5.67 g, 53.5 mmol) in 1, 4-dioxane (89 mL) was sparged with N2(g) for 3 min, then stirred at 110 C for 2 h. The reaction mixture was then partitioned between EtOAc and brine. The aqueous layer was further extracted with EtOAc, and the combined organic extracts were then dried over Na2SO4 and concentrated in vacuo. Chromatographic purification of the residue (silica gel, eluent: 0- 40% EtOAc-EtOH (3:1)/heptane) gave 6-methyl-3-(prop-1-en-2-yl)pyridin-2-amine (3.65 g, 24.6 mmol, 92 % yield) as a white solid. m/z (ESI, +ve ion): 149.1 (M+H)+.(2) 2-amino-3, 5-dibromo-6-methylpyridine was added to 200 ml of anhydrous tetrahydrofuran, and after stirring, the temperature was lowered to 0 C. 6.4 g (0.1 mol) of methyllithium was added, and after 1 h of reaction, (2) 2-amino-3, 5-dibromo-6-methylpyridine was added to 200 ml of anhydrous tetrahydrofuran, and after stirring, the temperature was lowered to 0 C. 6.4 g (0.1 mol) of methyllithium was added, and after 1 h of reaction, A mixture of

Computed Properties

Molecular Weight:187.04
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:185.97926
Monoisotopic Mass:185.97926
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:97.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 126325-46-0

Grade: Pharmaceutical Grade

Content: 99%

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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2-Amino-3-bromo-6-methylpyridine

CAS No.: 126325-46-0

Content: 99.00%

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Guide of 2-Amino-3-bromo-6-methylpyridine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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2-Amino-3-bromo-6-methylpyridine

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