5-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE

To a solution of 5-aminotetrahydroisoquinoline (3.68 g, 24.8 mmol) in 1, 4-dioxane (100 mL) was added 3 N NaOH (8. 27 mL, 24.8 mmol). After cooling to 0 °C, (Boc) 20 (5.42 g, 24.8 mmol) in 1, 4-dioxane (10 mL) was added drop-wise and stirred for overnight at room temperature. The reaction mixture was poured into water and extracted with EtOAc (2x). The combined organic layers was washed with sat. aq. NaHC03 solution, water, and brine, then dried and concentrated. The residue was purified by silica gel column chromatography to give 5.44 g (88percent) of the desired Boc-protected product as a white solid334B. tert-Butyl 5-amino-3, 4-dihydroisoquinoline-2(lH)-carboxylate: 334A was dissolved in dioxane (20 mL) and 1M NaOH (12.62 mL, 12.62 mmol) and B0C

Molecular Weight:248.32
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:248.152477885
Monoisotopic Mass:248.152477885
Topological Polar Surface Area:55.6
Heavy Atom Count:18
Complexity:311
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes