2-Amino-6-methoxybenzothiazole
-
2-Amino-6-methoxybenzothiazole
structure -
-
CAS No:
1747-60-0
-
Formula:
C8H8N2OS
-
Chemical Name:
2-Amino-6-methoxybenzothiazole
-
Synonyms:
2-Benzothiazolamine,6-methoxy-;Benzothiazole,2-amino-6-methoxy-;6-Methoxy-2-benzothiazolamine;6-Methoxy-2-aminobenzothiazole;2-Amino-6-methoxybenzothiazole;6-Methoxy-1,3-benzothiazol-2-ylamine;NSC 27516;(6-Methoxybenzothiazol-2-yl)amine;6-Methoxybenzo[d]thiazol-2-amine;6-Methoxy-1,3-benzothiazol-2-amine;6-(Methyloxy)-1,3-benzothiazol-2-amine
- Categories:
-
CAS No:
Description
off-white to tan-coloured powderFine off-white to light tan powder.
2-amino-6-methoxybenzothiazole is a fine off-white to light tan powder. (NTP, 1992)
2-amino-6-methoxybenzothiazole is a fine off-white to light tan powder. (NTP, 1992)
2-Amino-6-methoxybenzothiazole Basic Attributes
180.23
180.23
217-130-0
LAT2842YVX
27516
DTXSID9024485
29342080
Characteristics
76.4
2.4
White to beige or grayish-lilac Crystalline Powder
1.2425 (rough estimate)
158 °C
240°C
163.9±25.7 °C
1.5690 (estimate)
H2O: <0.1 g/100 mL at 21 ºC
0.000142mmHg at 25°C
Insoluble in water.
Amines, Phosphines, and Pyridines
2-AMINO-6-METHOXYBENZOTHIAZOLE may be sensitive to exposure to light. This chemical is incompatible with strong oxidizers. (NTP, 1992)
Safety Information
III
IRRITANT
2811
3
22-36/37/38-20/21/22
26-36
DL2100000
Xn,Xi
Irritant
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
P261-P305 + P351 + P338
H302-H315-H319-H335
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
|Warning|H302 (97.83%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to light. Keep it away from oxidizing materials and store it under ambient temperatures. (NTP, 1992)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Drug Information
SYMPTOMS: Symptoms of exposure to this compound include irritation. ACUTE/CHRONIC HAZARDS: This compound may be harmful by ingestion, inhalation or skin absorption. It may cause irritation. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide, sulfur oxides and nitrogen oxides. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
2-amino-6-methoxybenzothiazole
2-Amino-6-methoxybenzothiazole Use and Manufacturing
Firstly, p-anisidine hydrochloride and sodium thiocyanate are reacted to obtain p-methoxyphenyl thiourea, which is then obtained by ring closure with sulfur chloride. The process is as follows: (1) Add water to a glass-lined pot, heat to 60°C, slowly add p-anisole with stirring, and stir at 60-65°C for 30 minutes to completely dissolve it. Use 30% industrial hydrochloric acid to adjust the acidity of the solution. The Congo red test paper is slightly blue, maintain it for 10 minutes, add sodium thiocyanate, heat, and slowly raise the temperature to 105°C, and reflux at 105°C for 24h. Then cool to 25°C and filter. The filter cake is washed with water and dried to obtain p-methoxyphenyl thiourea. (2) Inhale anhydrous chloroform into a dry glass-lined pot, add dry p-methoxyphenylthiourea under stirring. Heat to 60-62°C, distill off part of the chloroform and water in the raw materials. Then it was cooled to 25°C and sulfur chloride was gradually added. After the addition, it was stirred at 30°C for 1 hour, and the temperature was raised to 43-45°C to react for 4 hours. Hydrogen chloride gas is produced during the reaction and absorbed by the absorption system. The reaction was refluxed at 62-64°C for 10 hours. Then cool to below 60°C, press the material into an acid distillation pot containing chimney ash (replacement of activated carbon) and water, and use direct steam distillation to recover chloroform until the temperature is 95°C and maintain it for 15 minutes. After the chloroform is recovered, stop the distillation, cool to 90°C, add water to adjust the volume, add ice to cool to 45°C, add 30% liquid caustic in a trickle, adjust the pH to 4-5, and stir for 15 minutes. Suction filtration, heating the filtrate to 60°C, using 30% liquid caustic soda to carry out alkaline precipitation of phenolphthalein, showing a reddish color. After suction filtration, the obtained filter cake is the finished product. Melting point 160-163℃, yield 85%.
Used as dye intermediate
2-Benzothiazolamine, 6-methoxy-: ACTIVE
Computed Properties
Molecular Weight:180.23
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:180.03573406
Monoisotopic Mass:180.03573406
Topological Polar Surface Area:76.4
Heavy Atom Count:12
Complexity:167
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Amino-6-methoxybenzothiazole
-
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
CN
2 YRS
Business licensed Certified factoryManufactory Supplier of Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate,Pigment & Dyestuff,Polymer,,Flavour & Fragrance,Basic Organic Chemicals,Pharmaceutical cosmetic additives,Veterinary APIs,Feed additives,Natural Nutrition Ingredients,Food Additives,Human APIs -
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals -
CN
3 YRS
Business licensedTrader Supplier of CHEMICALS,REAGENTSInquiryCAS No.: 1747-60-0Grade: Pharmaceutical GradeContent: 99% -
CN
3 YRS
Business licensed Certified factoryManufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
Learn More Other Chemicals
-
4,4′-Diaminobenzenesulfonanilide
16803-97-7
-
(4-methylphenyl)methyl thiocyanate
18991-39-4
-
(1s,4r)-4-Butyl-4'-(3,4,5-trifluorophenyl)-1,1'-bi(cyclohexyl)
139420-31-8
-
2-Anthracenesulfonic acid, 1-amino-9,10-dihydro-4-[(4-methyl-2-sulfophenyl)amino]-9,10-dioxo-, sodium salt (1:2) Formula
6408-80-6
-
4-Cyclohexylphenol Formula
1131-60-8
-
4-(Benzoylamino)-5-hydroxy-2,7-naphthalenedisulfonic acid Formula
117-46-4
-
Ethyl3,4-diaminobenzoate Structure
37466-90-3
-
Direct Blue 6 Structure
2602-46-2
-
What is 3,3-bis(1-butyl-2-methyl-1H-indol-3-yl)phthalide
50292-91-6
-
What is N-(4-Aminophenyl)acetamide
122-80-5