2-(6-BroMo-pyridin-3-yl)pyriMidine

A mixture of 2-bromopyrimidine (0.43g, 2.70mmol), 2-bromopyridine-5-boronic acid (0.55g, 2.72mmol), tetrakis(triphenylpnosphine)palladium(0) (3OOmg, 0.259mmol), cesium carbonate (1.15g, 3.03mmol) was stirred in MeOH/toluene/water (15ml, 1/1/1) at reflux temperature overnight. The reaction was cooled to room temperature and diluted with EtOAc (200ml) and water (50ml). The organic layer was separated, dried over MgSd, filtered and solvent evaporated yielding a residue which was purified on silica gel eluting with 25percent v/vEtOAc/hexanes yielding product 76 as white solid. (0.55g, 85percent) ESMS (MH, 236).A mixture of 2-bromopyridine (0.43g, 2.70mmol), 2-bromopyridine-5-boronic acid (0.55g, 2.72mmol), tetrakis(triphenylphosphine)palladium(0) (3OOmg, 0.259mmol), cesium carbonate (1.15g, 3.03mmol) was stirred in MeOH/toluene/water (15ml, 1/1/1) at reflux temperature overnight. The reaction was cooled to room temperature and diluted with EtOAc (200ml) and water (50ml). The organic layer was separated, dried over MgSO4, filtered and solvent evaporated yielding a residue which was purified on silica gel eluting with 25percent v/vEtOAc/hexanes yielding product 76 as white solid. (0.55g, 5percent) ESMS (MH, 236).

Molecular Weight:236.07
XLogP3:1.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:234.97451
Monoisotopic Mass:234.97451
Topological Polar Surface Area:38.7
Heavy Atom Count:13
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes