5-BroMo-7-fluoro-1-indanone

ΓΒ1 5-Bromo-7-fluoro-indan-l-oneTo a mixture of A1C1[B] Step 3: A mixture of sodium chloride (333 g, 5.69 mol) and aluminum trichloride (1270 g, 9.52 mol) was added to 144c (210 g, 0.79 mol) in several portions at 130 °C. See Figure 3. The neat reaction mixture was then stirred at 180°C. After 5h the reaction mixture was poured into a stirred solution of ice water (1000 mL) and concentrated HC1 (100 mL). The quenched reaction was stirred for 40 min and then extracted with DCM (4000 mL x 3). The combined organic phase was washed with saturated NaHCC>3 solution (1000 mL), brine (2000 mL x 2), dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (PE/EA=50/1, 10/1) to afford 55.0 g (30.4percent) of 5-bromo-7-fluoro-2, 3-dihydro-lH-inden-l-one 144d. *H NMR (400 MHz, CDC1

Molecular Weight:229.05
XLogP3:2.5
Hydrogen Bond Acceptor Count:2
Exact Mass:227.95861
Monoisotopic Mass:227.95861
Topological Polar Surface Area:17.1
Heavy Atom Count:12
Complexity:207
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes