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Lomitapide mesylate

Lomitapide mesylate structure

CAS No:
202914-84-9
Formula:
C39H37F6N3O2.xCH4O3S
Chemical Name:
Lomitapide mesylate
Synonyms:
9H-Fluorene-9-carboxamide,N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-,methanesulfonate (1:?);9H-Fluorene-9-carboxamide,N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-,methanesulfonate;BMS 201038 methanesulfonic acid salt;BMS 201038-04;Lomitapide mesylate;Juxtapid

Description

Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.IC50 value: 8 nM [1]Target: MTP inhibitorLomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or

Lomitapide mesylate is a methanesulfonate (mesylate) salt prepared from equimolar amounts of lomitapide and methanesulfonic acid. Used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. It has a role as an anticholesteremic drug and a MTP inhibitor. It contains a lomitapide(1+).|Lomitapide Mesylate is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.

Lomitapide mesylate Basic Attributes

Molecular Weight：

789.834

Exact Mass：

789.26700

UNII：

X4S83CP54E

DSSTox ID：

DTXSID60174170

NCI Thesaurus Code：

C83892

Characteristics

PSA：

124

XLogP3：

9.68660

Safety Information

Precautionary statement(s)：

P201, P202, P273, P281, P308+P313, P405, P501

Hazard Statements：

H351

GHS Classification：

|Danger|H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P273, P281, P308+P313, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

AEGR 733

Lomitapide mesylate Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:789.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:789.26711156
Monoisotopic Mass:789.26711156
Topological Polar Surface Area:124
Heavy Atom Count:55
Complexity:1200
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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BMS 201038-04

CAS No.: 202914-84-9

Content: 99.00%

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Guide of Lomitapide mesylate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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