Clostilbegit
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Clostilbegit
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CAS No:
50-41-9
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Formula:
C26H28ClNO.C6H8O7
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Chemical Name:
Clostilbegit
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Synonyms:
Ethanamine,2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-,2-hydroxy-1,2,3-propanetricarboxylate (1:1);Triethylamine,2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-,citrate (1:1);Triethylamine,2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-,citrate;MRL 41;Chloramiphene;2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine dihydrogen citrate;Clomid;1-[p-(β-Diethylaminoethoxy)phenyl]-1,2-diphenyl-2-chloroethylene citrate;Clomiphene citrate;Clomiphene dihydrogen citrate;Racemic clomiphene citrate;Clomifene citrate;Omifin;Clomifeno;Clomivid;Clomphid;Dyneric;Genozym;Ikaclomin;Mer 41;Fertyl;Fertivet;Clostilbegyt;Ikaclomine;Pergotime;Serophene;NSC 35770;Clostilbegit;Clomhexal;Siphene;Klomen;2-(4-(2-Chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate
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Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System
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CAS No:
Description
Clomifene Citrate is a selective estrogen receptor modulator.Target: Estrogen Receptor/ERRClomifene Citrate(CC) acted as an estrogen antagonist regardless of the concentration of E2 added together. In conclusion, CC acts as an estrogen agonist/antagonist via ER alpha in a coexisting estrogen concentration-dependent way whereas it acts as an estrogen antagonist via ER beta whether or not estrogen is present [1]. Clomiphene was effective in increasing pregnancy rate compared to placebo (OR
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.
Characteristics
144.60000
5.31410
white crystalline powder
116.5-118 °C
509ºC at 760 mmHg
261.6ºC
Slightly soluble in water, methanol, chloroform (slightly), and DMSO (10 mM). Insoluble in ether.
2-8ºC
LD50 oral in rat: 5750mg/kg
Safety Information
NONH for all modes of transport
3
R60;R63
S53-S36/37-S45
YE0875000
T:Toxic;
P280
H361
|Warning|H361 (91.49%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 47 companies from 7 notifications to the ECHA C&L Inventory.
Drug Information
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63) (See all compounds classified as Selective Estrogen Receptor Modulators.)|Compounds which increase the capacity to conceive in females. (See all compounds classified as Fertility Agents, Female.)|Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)
Chloramiphene
Clostilbegit Use and Manufacturing
An unducer of ovulation. A gonad-stimulating principle Synthetic estrogen agonist-antagonist. Gonad-stimulating principle. A selective estrogen receptor modulator Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:598.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:14
Exact Mass:597.2129448
Monoisotopic Mass:597.2129448
Topological Polar Surface Area:145
Heavy Atom Count:42
Complexity:708
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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