2-BROMO-4-CHLORO-1-NITRO-BENZENE
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2-BROMO-4-CHLORO-1-NITRO-BENZENE
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CAS No:
63860-31-1
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Formula:
C6H3BrClNO2
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Chemical Name:
2-BROMO-4-CHLORO-1-NITRO-BENZENE
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Synonyms:
2-bromo-4-chloro-1-nitrobenzene;2-bromo-4-chloro-1-nitro-benzene;2-Bromo-4-chloronitrobenzene;Benzene, 2-bromo-4-chloro-1-nitro-;MFCD08437614;2-Brom-4-chlornitrobenzol;SCHEMBL1511847;4-Nitro-3-bromophenyl chloride;CTK5C0001;KS-00000JUS
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CAS No:
2-BROMO-4-CHLORO-1-NITRO-BENZENE Use and Manufacturing
under nitrogen gas, 2-bromo-4-chloro- 1-nitrobenzene (25g, 0.107mol) was dissolved in THF (250mL), added dropwise vinylmagnesium bromoide (1M in THF, 321mL , 0.321mol) slowly -40 degree celcius , it was stirred at -40 degree celcius for 1 hour. Since, NH4After completion of the reaction with Cl aqueous solution was raised to room temperature.Then, the ethyl acetate was extracted into the organic layer, MgSO4to remove water from the organic layer to the next, filtered and concentrated and purified by column chromatography to give 7-bromo-5-chloro-1H-indole (7.89g, Yield: 32%) It was obtained.General procedure: A 25 mL round bottom flask equipped with Dimroth condenser (chilled to 10 C) was charged with nitroarenecarboxylic acid ArC02H (1.8 mmol), chloroisocyanurate, brominating agent and solvent (8 mL). The mixture was stirred and heated in an oil bath under fluorescent room light irradiation (FL). The cooled reaction mixture was filtered through short silica gel pad, washed with 1 M aq Na2S03, dried over Na2S04, filtered and concentrated in vacuo to obtain bromonitroarene ArBr. The obtained product contained between 1-5% of the corresponding chloronitroarene ArCl as a by-product. The results are presented in Table 2. Table 2. Bromodecarboxylation of nitroarenecarboxylic acids ArC02H aThe starting material, 2-([1, 1'-biphenyl]-4-yl)-4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolane (53.28 g, 190.2 mmol) was dissolved in THF in a round bottom flask,
Computed Properties
Molecular Weight:236.45
XLogP3:3.2
Hydrogen Bond Acceptor Count:2
Exact Mass:234.90357
Monoisotopic Mass:234.90357
Topological Polar Surface Area:45.8
Heavy Atom Count:11
Complexity:161
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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