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Calyculin A

Calyculin A structure

CAS No:
101932-71-2
Formula:
C50H81N4O15P
Chemical Name:
Calyculin A
Synonyms:
L-Ribonamide,N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propen-1-yl]-2-oxazolyl]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-;L-Ribonamide,N-[3-[4-[3-[2-(14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl)-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazolyl]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-,[5R-[5α[2R*(1S*,3S*,4S*,5R*,6R*,7E,9E,11E,13Z),3R*],7β[E(S*)],8β,9α]]-;L-Ribonamide,N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazolyl]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-;1,6-Dioxaspiro[4.5]decane,L-ribonamide deriv.;N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propen-1-yl]-2-oxazolyl]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide;Calyculin A;(-)-Calyculin A

Description

Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.5 to 1 nM.

Calyculin A Basic Attributes

Molecular Weight：

1009.17

Exact Mass：

1009.17

Characteristics

PSA：

296.80000

XLogP3：

5.07988

Appearance：

white solid

Density：

1.25±0.1 g/cm3(Predicted)

Melting Point：

247-249°

Refractive Index：

1.57

Water Solubility：

soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.

Storage Conditions：

−20°C

Specific rotation：

D -60° (c = 0.1 in ethanol)

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 3462 6.1/PG 3

wgk germany：

hazard class code：

23/24/25-38

safety instructions：

36/37/39-45

Marks：

Precautionary statement(s)：

P261-P280-P301 + P310-P311

Hazard Statements：

H301 + H311 + H331-H315

Calyculin A Use and Manufacturing

Inhibitor of phosphatases 1 and 2a.

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Calyculin A

CAS No.: 101932-71-2

Content: 99%

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Guide of Calyculin A

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
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Calyculin A

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