Bucloxic acid
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Bucloxic acid
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CAS No:
32808-51-8
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Formula:
C16H19ClO3
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Chemical Name:
Bucloxic acid
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Synonyms:
Benzenebutanoic acid,3-chloro-4-cyclohexyl-γ-oxo-;Propionic acid,3-(3-chloro-4-cyclohexylbenzoyl)-;3-Chloro-4-cyclohexyl-γ-oxobenzenebutanoic acid;4-(m-Chloro-p-cyclohexylphenyl)-4-oxobutyric acid;Bucloxic acid;804CB;Esfar;Bucloxonic acid;3-(3-Chloro-4-cyclohexylbenzoyl)propionic acid
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CAS No:
Description
Bucloxic acid is an anti-inflammatory pyrrazole derivative. Bucloxic acid can be used in the treatment of chronic glomerular nephropathies.
Bucloxic acid is an aromatic ketone.
Characteristics
54.4
4.43520
1.219g/cm3
163 °C
482ºC at 760mmHg
245.3ºC
1.557
LD50 in mice, rats (mg/kg): 900, 120 orally; 1100, 210 i.p (Krausz, p. 1360)
Drug Information
Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS. (See all compounds classified as Neuromuscular Agents.)
4-(3-chloro-4-cyclohexylphenyl)-4-oxobutyric acid
Bucloxic acid Use and Manufacturing
It is derived from 4-(4'-cyclohexylphenyl)-4-one butyric acid by chlorination and salt formation.
This product is an anti-inflammatory analgesic. The oral LD50 of mice is 1700mg/kg, rats 175mg/kg; the intraperitoneal injection of mice LD50 is 1700mg/kg, rats 200mg/kg.
Computed Properties
Molecular Weight:294.77
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:294.1022722
Monoisotopic Mass:294.1022722
Topological Polar Surface Area:54.4
Heavy Atom Count:20
Complexity:350
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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