6-chloro-5-methyl-2H-pyridazin-3-one
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6-chloro-5-methyl-2H-pyridazin-3-one
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CAS No:
1703-07-7
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Formula:
C5H5ClN2O
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Chemical Name:
6-chloro-5-methyl-2H-pyridazin-3-one
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Synonyms:
6-chloro-5-methyl-2H-pyridazin-3-one;6-Chloro-5-Methylpyridazin-3(2H)-one;3(2H)-Pyridazinone, 6-chloro-5-Methyl-;6-Chloro-3-hydroxy-5-methylpyridazine;6-Chloro-5-methylpyridazin-3-ol, 6-Chloro-3-hydroxy-5-methyl-1,2-diazine;3-chloro-4-methyl-1H-pyridazin-6-one
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
6-chloro-5-methyl-2H-pyridazin-3-one Use and Manufacturing
3, 6-Dichloro-4-methylpyridazine (30.6 g, 190 mmol) was suspended in glacial AcOH (800 mL) at ambient temperature and heated in an oil bath thermostatted at 110-115 °C for 3 h. (The mixture became homogenous after 1 h.) The mixture was allowed to cool and the AcOH was removed by vacuum distillation. The resulting solid residue was slowly treated with sat. NaHCOIntermediate VII6-Chloro-4-methyl-2H-pyridazin-3-one and 6-chloro-5-methyl-2H-pyridazin-3-one A suspension of 3, 6-dichloro-4-methylpyridazine (6.60 g) in 3.3 M aqueous NaOH solution (66 mL) was stirred at reflux temperature for 2 h. The heating bath was removed and 50percent aqueous acetic acid (25 mL) was added. The aqueous solution was adjusted to pH value 6 and the precipitate formed thereafter was separated by filtration and washed with little water. The precipitate was chromatographed on silica gel (cyclohexane/ethyl acetate 90:10->0:100) to separate the two title compounds.6-Chloro-4-methyl-2H-pyridazin-3-one: Yield: 2.70 g (46percent of theory). Mass spectrum (ESI
6-chloro-5-methyl-2H-pyridazin-3-one
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