COMPOUND 52
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COMPOUND 52
structure -
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CAS No:
212779-48-1
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Formula:
C16H19ClN6O
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Chemical Name:
COMPOUND 52
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Synonyms:
NG-52;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE;COMPOUND 52;2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine,NG-52;2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol;2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]ethanol;NG 52 (Compound 52 )
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CAS No:
Description
NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).IC50 value: 7 uM [1]Target: Cdc28pCompound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM).
Characteristics
91.12000
1.54
white to off-white powder
1.4±0.1 g/cm3
587.7±60.0 °C at 760 mmHg
309.2±32.9 °C
1.688
methylene chloride: 50 mg/mL, clear, colorless
−20°C
Computed Properties
Molecular Weight:346.81
XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:346.1308869
Monoisotopic Mass:346.1308869
Topological Polar Surface Area:87.9
Heavy Atom Count:24
Complexity:401
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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