4,5-Dianilinophthalimide
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4,5-Dianilinophthalimide
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CAS No:
145915-58-8
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Formula:
C20H15N3O2
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Chemical Name:
4,5-Dianilinophthalimide
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Synonyms:
1H-Isoindole-1,3(2H)-dione,5,6-bis(phenylamino)-;5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione;4,5-Dianilinophthalimide;CGP 52411;DAPH;157168-02-0
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CAS No:
Description
CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitive EGFR inhibitor with an IC50 of 0.3 μM. CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells, and dramatic inhibits and reverses the formation of β-amyloid (Aβ42) fibril aggregates associated with Alzheimer's disease[1][2].
4,5-dianilinophthalimide is phthalimide substituted at the 4- and 5-positions by anilino groups. It has a role as a tyrosine kinase inhibitor.
Drug Information
Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)
4,5-dianilinophthalimide
Computed Properties
Molecular Weight:329.4
XLogP3:3.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:329.116426730
Monoisotopic Mass:329.116426730
Topological Polar Surface Area:70.2
Heavy Atom Count:25
Complexity:453
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes