5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

Off-white to light yellow solid

General procedure: A mixture of 1a, b ( 1 mmol) and formamide( 5-6 mmol) in ( 1 mmol) acetic acid, was irradiationin the microwave oven for 10 min. at (300 W) 130 °C.The reaction mixture was cooled and poured intoiced-cold water, filtered, washed and recrystallized from ethanol. . 5, 6-Dimethyl-3H-thieno[2, 3-d]pyrimidin-4-one (4a) M.p. 180-183 °C; IR(cmGeneral procedure: A mixture of 1a, b ( 1 mmol) and formamide( 5-6 mmol) in ( 1 mmol) acetic acid, was irradiationin the microwave oven for 10 min. at (300 W) 130 °C.The reaction mixture was cooled and poured intoiced-cold water, filtered, washed and recrystallized from ethanol. 5, 6-Dimethyl-3H-thieno[2, 3-d]pyrimidin-4-one (4a) M.p. 180-183 °C; IR(cmTake 19.9g (0.1mol) 2- amino-4, 5-dimethyl-thiophene-3-carboxylate in 100ml of formamide, heated at reflux for 6 hours, monitored by TLC after completion of the reaction, the reaction solution was cooled to room temperature, was added 100ml of water, stirring was continued for 1 hour, and filtered to give 15.3 g of soil gray solid, 85percent yield, m.p. 274-275 .General procedure: The different ethyl 2-aminothiophene-3-carboxylate (5a-g) (1 eq.) and formamide (3.2mL/mmol eq.) were refluxed for 8 h. The reaction mixture was then cooled in an ice-bath and added of cold water. The precipitate formed was collected by filtration, washed thoroughly with cold water and purified by crystallisation from EtOH/H2O unless otherwise stated.

Molecular Weight:180.23
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:180.03573406
Monoisotopic Mass:180.03573406
Topological Polar Surface Area:69.7
Heavy Atom Count:12
Complexity:241
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes