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6-Maleimidocaproic acid

6-Maleimidocaproic acid structure

CAS No:
55750-53-3
Formula:
C10H13NO4
Chemical Name:
6-Maleimidocaproic acid
Synonyms:
1H-Pyrrole-1-hexanoic acid,2,5-dihydro-2,5-dioxo-;2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid;N-(5-Carboxypentyl)maleimide;6-Maleimidohexanoic acid;6-Maleimidocaproic acid;ε-Maleimidocaproic acid;N-(5-Carboxy-n-pentyl)maleimide;6-Maleimidocapronic acid;ε-Maleimidohexanoic acid;6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid
Categories:
Pharmaceutical Intermediates > Antineoplastics

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Description

6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

6-Maleimidocaproic acid is a medium-chain fatty acid.

6-Maleimidocaproic acid Basic Attributes

Molecular Weight：

211.21

Exact Mass：

211.21

EC Number：

1533716-785-6

HScode：

2925190090

Characteristics

PSA：

74.7

XLogP3：

1.1

Appearance：

White to pale yellow Powder

Density：

1.3±0.1 g/cm3

Melting Point：

78 °C @ Solvent: Ethyl acetate

Boiling Point：

407.3ºC at 760 mmHg

Flash Point：

200.1±24.0 °C

Refractive Index：

1.537

Water Solubility：

soluble in water, methanol, ethanol, dimethyl sulfoxide. Insoluble in ether.

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-41-37/38

safety instructions：

26-36-39

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H315-H318-H335

GHS Classification：

|Danger|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 52 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

EMCA

6-Maleimidocaproic acid Use and Manufacturing

Asulfhydryl reactive heterobifunctional crosslinking reagent. Widely used probe for introducing maleimides groups into biomolecules.A probe for thiol groups in proteins.Spacer Arm: 9.4 Angstroms

Computed Properties

Molecular Weight:211.21
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:211.08445790
Monoisotopic Mass:211.08445790
Topological Polar Surface Area:74.7
Heavy Atom Count:15
Complexity:291
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 6-Maleimidocaproic acid

Shandong zhishang chemical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Dichloromethane,Linocaine hydrochloride

55750-53-3 6-Maleimidocaproic acid powder

CAS No.: 55750-53-3

Grade: Cosmetics Grade

Content: 98%

Inquiry
Shandong Ranhang Biotechnology Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of chemical

Ranhang 6-Maleimidocaproic acid 55750-53-3

CAS No.: 55750-53-3

Grade: Pharmaceutical Grade

Content: 99%

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