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Esorubicin

Esorubicin structure

CAS No:
63521-85-7
Formula:
C27H29NO10
Chemical Name:
Esorubicin
Synonyms:
5,12-Naphthacenedione,10-[[(2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-;5,12-Naphthacenedione,10-[(4-aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,[2S-[2α(8R*,10R*),4β,6β]]-;5,12-Naphthacenedione,10-[[(2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S,10S)-;(8S,10S)-10-[[(2S,4R,6S)-4-Aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;4′-Deoxyadriamycin;4′-Deoxydoxorubicin;Esorubicin;Deoxydoxorubicin
Categories:
Biochemical Engineering > Saccharides

Description

Esorubicin is a synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin with potential antineoplastic activity. Esorubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause more severe myelosupression compared to other compounds within the anthracycline class.

Esorubicin Basic Attributes

Molecular Weight：

527.523

Exact Mass：

527.52

UNII：

RMC41L2WQ3

NCI Thesaurus Code：

C972

Characteristics

PSA：

186

XLogP3：

1.73080

Density：

1.55g/cm3

Boiling Point：

765.8ºC at 760 mmHg

Flash Point：

416.9ºC

Refractive Index：

1.693

Drug Information

MeSH：

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

MeSH Entry Terms：

4'-deoxyadriamycin

Esorubicin Use and Manufacturing

Antineoplastic.

Computed Properties

Molecular Weight:527.5
XLogP3:2.2
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:5
Exact Mass:527.17914612
Monoisotopic Mass:527.17914612
Topological Polar Surface Area:186
Heavy Atom Count:38
Complexity:945
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Decarboxylated AdoMet Formula

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Guide of Esorubicin

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

Esorubicin

SDS

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