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Ethoxysanguinarine

Ethoxysanguinarine structure

CAS No:
28342-31-6
Formula:
C22H18NO5
Chemical Name:
Ethoxysanguinarine
Synonyms:
Ethoxysanguinarine;($$+/-$$)-Sanguinarine pseudoethanolate;14-Ethoxy-13,14-dihydrosanguinarine;14-Ethoxy-13-Methyl-13,14-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridine;14-Ethoxy-13,14-dihydrosanguinarine(±)-Sanguinarine pseudoethanolate;6-Ethoxysanguinarine;6-Ethoxydihydrosanguinarine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine inhibits viability and induces apoptosis of colorectal cancer cells by inhibiting protein phosphatase 2A (CIP2A)[1].

Ethoxysanguinarine Basic Attributes

Molecular Weight：

376.386

Exact Mass：

377.126312

DSSTox ID：

DTXSID90415720

HScode：

2933990090

Characteristics

PSA：

50.03000

XLogP3：

4.45

Density：

1.5±0.1 g/cm3

Melting Point：

210-212℃ (ethanol )

Boiling Point：

563.7±50.0 °C at 760 mmHg

Flash Point：

169.0±27.3 °C

Refractive Index：

1.724

Vapor Pressure：

9.92E-13mmHg at 25°C

Computed Properties

Molecular Weight:377.4
XLogP3:4.5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:377.12632271
Monoisotopic Mass:377.12632271
Topological Polar Surface Area:49.4
Heavy Atom Count:28
Complexity:589
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes