Azetidine, 3-ethoxy-, hydrochloride (1:1)

To a solution of 5-chloropyridazin-3(2H)-one (130 mg, 0.946 mmol) in N, N-d i mcth yl acctam idc (2.5 mL) were added potassium carbonate (654 mg, 4.73 mmol) and A mixture of 4, 5-dichloro-2-[[5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl]methyl]pyridazin-3- one (50 mg, 0.142 mmol), General procedure: To a stirred suspension of 5-chloro-2-[[5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4- yl]methyl]pyridazin-3-one (building block A, 300 mg, 0.947 mmol) and (R)-3- hydroxypyrrolidine (0.14 mL, 1.73 mmol) in DMSO (0.5 mL) and acetonitrile (3 mL) was added potassium carbonate (393 mg, 2.84 mmol) Then the reaction mixture was stirred at 70 C for 18 h. After cooling to room temperature the reaction mixture was diluted with EtOAc (80 mL) was washed three times with water (10 mL) and brine (10 mL). The aqueous layers were back extracted twice with EtOAc (80 mL). The combined organic extracts were dried (Na2S04), filtered and concentrated in vacuo. Purification by flash chromatography (silica, gradient: 0% to 10% MeOH in CH2CI2) afforded the title compound (341 mg, 93 %) as an off-white foam. MS (ESI): 368.2 ([M+H]+).To 5- [(4, 6-dimethyl-2-oxo- 1 , 2-dihydropyridin-3-yl)methyl] -3 -methyl-2-[methyl(4-oxocyclohexyl)amino] -5, 6, 7, 8-tetrahydro-4H-thieno [3, 2-c]azepin-4-one (0.320 g, 0.616 mmol) in THF (10 mL), add To a crude sample of methyl 2-bromo-5- [ethyl(4-oxocyclohexyl)amino] -4-methylthiophene-3-carboxylate (2.17 g, 5.80 mmol) in DCM (20 mL), add titanium(W) isopropoxide (6.79 g, 23.2 nimol) and

Molecular Weight:137.61
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:137.0607417
Monoisotopic Mass:137.0607417
Topological Polar Surface Area:21.3
Heavy Atom Count:8
Complexity:52
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes